12yu: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary Tag: Manual revert |
No edit summary |
||
| Line 1: | Line 1: | ||
==Crystal structure of the BPTF PHD finger-Bromodomain bound to H3R2X3K4me3== | |||
<StructureSection load='12yu' size='340' side='right'caption='[[12yu]], [[Resolution|resolution]] 1.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[12yu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=12YU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=12YU FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1DEJ:(2~{S})-2-azanyl-5-(3-methylbenzimidazol-1-yl)pentanoic+acid'>A1DEJ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=12yu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=12yu OCA], [https://pdbe.org/12yu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=12yu RCSB], [https://www.ebi.ac.uk/pdbsum/12yu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=12yu ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/BPTF_HUMAN BPTF_HUMAN] Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Shao Z]] | |||
[[Category: Song J]] | |||
Latest revision as of 16:13, 25 September 2026
Crystal structure of the BPTF PHD finger-Bromodomain bound to H3R2X3K4me3
| ||||||||||||
