9wvk: Difference between revisions

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'''Unreleased structure'''


The entry 9wvk is ON HOLD  until Paper Publication
==Crystal structure of human NIPBL C-terminal domain==
 
<StructureSection load='9wvk' size='340' side='right'caption='[[9wvk]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
Authors: Gupta, S., Roy, S.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9wvk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9WVK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9WVK FirstGlance]. <br>
Description: Crystal structure of human NIPBL C-terminal domain
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
[[Category: Gupta, S]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9wvk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9wvk OCA], [https://pdbe.org/9wvk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9wvk RCSB], [https://www.ebi.ac.uk/pdbsum/9wvk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9wvk ProSAT]</span></td></tr>
[[Category: Roy, S]]
</table>
== Disease ==
[https://www.uniprot.org/uniprot/NIPBL_HUMAN NIPBL_HUMAN] Cornelia de Lange syndrome;5p13 microduplication syndrome. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/NIPBL_HUMAN NIPBL_HUMAN] Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity).[UniProtKB:Q6KCD5]<ref>PMID:22628566</ref> <ref>PMID:28167679</ref> <ref>PMID:28914604</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Gupta S]]
[[Category: Roy S]]
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