11rl: Difference between revisions

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'''Unreleased structure'''


The entry 11rl is ON HOLD  until Paper Publication
==CryoEM structure of the human origin recognition complex with DNA and CDC6 protein==
 
<StructureSection load='11rl' size='340' side='right'caption='[[11rl]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
Authors: Chouhan, O.P., Joshua Tor, L.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[11rl]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/DNA_molecule DNA molecule] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=11RL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=11RL FirstGlance]. <br>
Description: CryoEM structure of the human origin recognition complex with DNA and CDC6 protein
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
[[Category: Joshua Tor, L]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=11rl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=11rl OCA], [https://pdbe.org/11rl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=11rl RCSB], [https://www.ebi.ac.uk/pdbsum/11rl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=11rl ProSAT]</span></td></tr>
[[Category: Chouhan, O.P]]
</table>
== Function ==
[https://www.uniprot.org/uniprot/ORC2_HUMAN ORC2_HUMAN] Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3.<ref>PMID:22427655</ref> <ref>PMID:22935713</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: DNA molecule]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Chouhan OP]]
[[Category: Joshua Tor L]]
Retrieved from "https://proteopedia.org/11rl"