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'''Unreleased structure'''


The entry 9ntw is ON HOLD  until Paper Publication
==Cryo-EM structure of BETP-oxyntomodulin-GLP_1R-Gs complex==
 
<StructureSection load='9ntw' size='340' side='right'caption='[[9ntw]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
Authors: Zhang, X., Belousoff, M.J., Sexton, P.M., Wootten, D.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9ntw]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Lama_glama Lama glama] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9NTW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9NTW FirstGlance]. <br>
Description: Cryo-EM structure of BETP-oxyntomodulin-GLP_1R-Gs complex
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1B06:(4M)-4-[3-(benzyloxy)phenyl]-2-(ethanesulfinyl)-6-(trifluoromethyl)pyrimidine'>A1B06</scene></td></tr>
[[Category: Zhang, X]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ntw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ntw OCA], [https://pdbe.org/9ntw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ntw RCSB], [https://www.ebi.ac.uk/pdbsum/9ntw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ntw ProSAT]</span></td></tr>
[[Category: Belousoff, M.J]]
</table>
[[Category: Sexton, P.M]]
== Disease ==
[[Category: Wootten, D]]
[https://www.uniprot.org/uniprot/GNAS2_HUMAN GNAS2_HUMAN] Pseudopseudohypoparathyroidism;Pseudohypoparathyroidism type 1A;Progressive osseous heteroplasia;Polyostotic fibrous dysplasia;Monostotic fibrous dysplasia;Pseudohypoparathyroidism type 1C;Pseudohypoparathyroidism type 1B;McCune-Albright syndrome. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry. Most affected individuals have defects in methylation of the gene. In some cases microdeletions involving the STX16 appear to cause loss of methylation at exon A/B of GNAS, resulting in PHP1B. Paternal uniparental isodisomy have also been observed.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/GNAS2_HUMAN GNAS2_HUMAN] Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs) (PubMed:17110384). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP (PubMed:26206488, PubMed:8702665). GNAS functions downstream of several GPCRs, including beta-adrenergic receptors (PubMed:21488135). Stimulates the Ras signaling pathway via RAPGEF2 (PubMed:12391161).<ref>PMID:12391161</ref> <ref>PMID:17110384</ref> <ref>PMID:21488135</ref> <ref>PMID:26206488</ref> <ref>PMID:8702665</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Lama glama]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Belousoff MJ]]
[[Category: Sexton PM]]
[[Category: Wootten D]]
[[Category: Zhang X]]
Retrieved from "https://proteopedia.org/9ntw"