9tmk: Difference between revisions

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'''Unreleased structure'''


The entry 9tmk is ON HOLD  until Paper Publication
==Structure of CYLD CAP-Gly2 bound to Listeria effector protein InlC==
 
<StructureSection load='9tmk' size='340' side='right'caption='[[9tmk]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
Authors: Ellison, C.J., Elliott, P.R.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9tmk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9TMK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9TMK FirstGlance]. <br>
Description: Structure of CYLD CAP-Gly2 bound to Listeria effector protein InlC
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
[[Category: Elliott, P.R]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9tmk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9tmk OCA], [https://pdbe.org/9tmk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9tmk RCSB], [https://www.ebi.ac.uk/pdbsum/9tmk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9tmk ProSAT]</span></td></tr>
[[Category: Ellison, C.J]]
</table>
== Function ==
[https://www.uniprot.org/uniprot/INLC_LISMG INLC_LISMG] A virulence enhancer that has at least 2 dissociable functions in infection; it impairs translocation of host transcription factor NF-kappa-B to the nucleus and antagonizes the function of the Tuba dynamin-binding protein, promoting bacterial spreading (PubMed:19767742, PubMed:20855622, PubMed:24332715). Perturbs the morphology of host cell junctions by impairing host DNMBP (Tuba) and WASL interaction, altering cortical tension at the cell junctions and allowing bacteria to more efficiently form bacteria-filled cell protrusions which promote bacterial spreading within infected host tissue (PubMed:19767742, PubMed:24332715). Down-regulates the host inflammation response usually induced by Listeria infection. Interacts with host I-kappa-B kinase alpha (IKKA, CHUK), which prevents IKKA from phosphorylating NF-kappa-B inhibitor alpha (IKBA, NFKBIA) and thus delays degradation of phospho-IKBA. Translocation of host transcription factor p65 (a subunit of NF-kappa-B, RELA) into the nucleus is impaired, which prevents activation of NF-KB-regulated genes (PubMed:20855622). Recognized by serum from healthy humans exposed to L.monocytogenes as well from patients who have recovered from listeriosis (PubMed:9284184).<ref>PMID:19767742</ref> <ref>PMID:20855622</ref> <ref>PMID:24332715</ref> <ref>PMID:9284184</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Listeria monocytogenes]]
[[Category: Elliott PR]]
[[Category: Ellison CJ]]
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