9y1m: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry 9y1m is ON HOLD until Paper Publication~~

==Cryo EM Structure of Full Length mGluR8 in Complex with Beta-Arrestin-1 Bound to Agonist L-AP4 and PAM VU6005649==

~~Authors: Marx, D.C., Levitz, J.T.~~

== Structural highlights ==

<table><tr><td colspan='2'>[[9y1m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9Y1M OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9Y1M FirstGlance].

~~Description:~~ Cryo EM Structure of Full Length mGluR8 in Complex with Beta-Arrestin-1 Bound to Agonist L-AP4 and PAM VU6005649

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.32Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1BWG:(3P,8S)-3-(2,3-difluoro-4-methoxyphenyl)-2,5-dimethyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine'>A1BWG</scene>, <scene name='pdbligand=E7P:(2~{S})-2-azanyl-4-phosphono-butanoic+acid'>E7P</scene></td></tr>

[[Category: Levitz~~, J.T~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9y1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9y1m OCA], [https://pdbe.org/9y1m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9y1m RCSB], [https://www.ebi.ac.uk/pdbsum/9y1m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9y1m ProSAT]</td></tr>

[[Category: Marx~~, D.C~~]]

</table>

== Function ==

[https://www.uniprot.org/uniprot/GRM8_HUMAN GRM8_HUMAN] G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.<ref>PMID:9473604</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Levitz JT]]

[[Category: Marx DC]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9y1m is ON HOLD  until Paper Publication
+==Cryo EM Structure of Full Length mGluR8 in Complex with Beta-Arrestin-1 Bound to Agonist L-AP4 and PAM VU6005649==
+<StructureSection load='9y1m' size='340' side='right'caption='[[9y1m]], [[Resolution|resolution]] 3.32&Aring;' scene=''>
-Authors: Marx, D.C., Levitz, J.T.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9y1m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9Y1M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9Y1M FirstGlance]. <br>
-Description: Cryo EM Structure of Full Length mGluR8 in Complex with Beta-Arrestin-1 Bound to Agonist L-AP4 and PAM VU6005649
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.32&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1BWG:(3P,8S)-3-(2,3-difluoro-4-methoxyphenyl)-2,5-dimethyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine'>A1BWG</scene>, <scene name='pdbligand=E7P:(2~{S})-2-azanyl-4-phosphono-butanoic+acid'>E7P</scene></td></tr>
-[[Category: Levitz, J.T]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9y1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9y1m OCA], [https://pdbe.org/9y1m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9y1m RCSB], [https://www.ebi.ac.uk/pdbsum/9y1m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9y1m ProSAT]</span></td></tr>
-[[Category: Marx, D.C]]
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/GRM8_HUMAN GRM8_HUMAN] G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.<ref>PMID:9473604</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Levitz JT]]
+[[Category: Marx DC]]