9zoe: Difference between revisions
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==Structure of RyR1 in complex with rosuvastatin (Ca2+/CFF/ATP dataset; open pore)== | |||
<StructureSection load='9zoe' size='340' side='right'caption='[[9zoe]], [[Resolution|resolution]] 2.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9zoe]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9ZOE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9ZOE FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1C3Z:N-[4-(4-fluorophenyl)-5-{(E)-2-[(2S,4R)-4-hydroxy-6-oxooxan-2-yl]ethen-1-yl}-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide'>A1C3Z</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CFF:CAFFEINE'>CFF</scene>, <scene name='pdbligand=PCW:1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PCW</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9zoe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9zoe OCA], [https://pdbe.org/9zoe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9zoe RCSB], [https://www.ebi.ac.uk/pdbsum/9zoe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9zoe ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/FKB1A_RABIT FKB1A_RABIT] Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Oryctolagus cuniculus]] | |||
[[Category: Marks AR]] | |||
[[Category: Weninger G]] | |||
Latest revision as of 09:52, 30 September 2026
Structure of RyR1 in complex with rosuvastatin (Ca2+/CFF/ATP dataset; open pore)
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