9ye2: Difference between revisions

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'''Unreleased structure'''


The entry 9ye2 is ON HOLD  until Paper Publication
==Crystal Structure of the GRAM-4 antibody fragment in complex with NAGG peptide==
<StructureSection load='9ye2' size='340' side='right'caption='[[9ye2]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9ye2]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Plasmodium_vivax Plasmodium vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9YE2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9YE2 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ye2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ye2 OCA], [https://pdbe.org/9ye2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ye2 RCSB], [https://www.ebi.ac.uk/pdbsum/9ye2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ye2 ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Circumsporozoite protein (CSP) is the most abundant Plasmodium sporozoite surface antigen. It is the major component of licensed Plasmodium falciparum vaccines and, hence, is the logical lead candidate for Plasmodium vivax (P. vivax) vaccines. However, our limited knowledge of protective B cell epitopes on P. vivax CSP remains a major roadblock. Here we identified two Plasmodium vivax CSP (PvCSP) B cell epitopes, PvCSP-A and PvCSP-B/NAGG, by screening inhibitory plasma from P. vivax-infected individuals. The epitopes were located in the N- and C-terminal regions of PvCSP, respectively, and were distinct from the canonical central repeat region epitope. We isolated a monoclonal antibody, GRAM-4, that recognized the PvCSP-B/NAGG epitope and mediated potent inhibition of traversal, hepatocyte invasion, and liver-stage development in vitro, confirming PvCSP-B/NAGG as a genuine neutralization target. Structural resolution of the GRAM-4:PvCSP-B/NAGG interaction at 2.65 A revealed the molecular basis of epitope recognition, providing a blueprint for PvCSP vaccine development.


Authors: Staker, B.L., Visweswaran, G.R., Vigdorovich, V., Sather, D.N., Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Targeting a site of vulnerability on circumsporozoite protein inhibits Plasmodium vivax malaria infection.,Visweswaran GRR, Mahdavi P, Vijayan K, Ntumngia FB, Staker BL, Barnes SJ, Subramani PA, Raappana A, Dambrauskas N, Glennon EKK, Kolli SK, Ogbondah MM, Watson A, Camargo N, Sankaran B, Thawornpan P, Jenwithisuk R, Myler PJ, Kappe SHI, Roobsoong W, Chootong P, Sattabongkot J, Kaushansky A, Vigdorovich V, Adams JH, Sather DN Immunity. 2026 Sep 24:S1074-7613(26)00376-6. doi: 10.1016/j.immuni.2026.09.001. PMID:42785294<ref>PMID:42785294</ref>


Description: Crystal Structure of the GRAM-4 antibody fragment in complex with NAGG peptide
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Seattle Structural Genomics Center For Infectious Disease (Ssgcid)]]
<div class="pdbe-citations 9ye2" style="background-color:#fffaf0;"></div>
[[Category: Visweswaran, G.R]]
== References ==
[[Category: Sather, D.N]]
<references/>
[[Category: Staker, B.L]]
__TOC__
[[Category: Vigdorovich, V]]
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Plasmodium vivax]]
[[Category: Sather DN]]
[[Category: Staker BL]]
[[Category: Vigdorovich V]]
[[Category: Visweswaran GR]]
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