1z7s: Difference between revisions
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{{STRUCTURE_1z7s| PDB=1z7s | SCENE= }} | |||
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'''The crystal structure of coxsackievirus A21''' | '''The crystal structure of coxsackievirus A21''' | ||
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[[Category: Wimmer, E.]] | [[Category: Wimmer, E.]] | ||
[[Category: Xiao, C.]] | [[Category: Xiao, C.]] | ||
[[Category: | [[Category: Icosahedral virus]] | ||
[[Category: | [[Category: Picornavirus,coxsackievirus,a21,capsid protein,viral protein]] | ||
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Revision as of 14:17, 3 May 2008
The crystal structure of coxsackievirus A21
Overview
CVA21 and polioviruses both belong to the Enterovirus genus in the family of Picornaviridae, whereas rhinoviruses form a distinct picornavirus genus. Nevertheless, CVA21 and the major group of human rhinoviruses recognize intercellular adhesion molecule-1 (ICAM-1) as their cellular receptor, whereas polioviruses use poliovirus receptor. The crystal structure of CVA21 has been determined to 3.2 A resolution. Its structure has greater similarity to poliovirus structures than to other known picornavirus structures. Cryo-electron microscopy (cryo-EM) was used to determine an 8.0 A resolution structure of CVA21 complexed with an ICAM-1 variant, ICAM-1(Kilifi). The cryo-EM map was fitted with the crystal structures of ICAM-1 and CVA21. Significant differences in the structure of CVA21 with respect to the poliovirus structures account for the inability of ICAM-1 to bind polioviruses. The interface between CVA21 and ICAM-1 has shape and electrostatic complementarity with many residues being conserved among those CVAs that bind ICAM-1.
About this Structure
1Z7S is a Protein complex structure of sequences from Human coxsackievirus a21. Full crystallographic information is available from OCA.
Reference
The crystal structure of coxsackievirus A21 and its interaction with ICAM-1., Xiao C, Bator-Kelly CM, Rieder E, Chipman PR, Craig A, Kuhn RJ, Wimmer E, Rossmann MG, Structure. 2005 Jul;13(7):1019-33. PMID:16004874 Page seeded by OCA on Sat May 3 17:17:07 2008
