2bdy: Difference between revisions
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[[Image:2bdy.jpg|left|200px]] | [[Image:2bdy.jpg|left|200px]] | ||
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'''thrombin in complex with inhibitor''' | '''thrombin in complex with inhibitor''' | ||
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[[Category: Thrombin]] | [[Category: Thrombin]] | ||
[[Category: Xue, Y.]] | [[Category: Xue, Y.]] | ||
[[Category: | [[Category: Complex structure]] | ||
[[Category: | [[Category: Thrombin]] | ||
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Revision as of 17:09, 3 May 2008
thrombin in complex with inhibitor
Overview
Prototypical thrombin inhibitors were synthesized based on a trisubstituted phenol as a core motif. A naphthylsulfonamide analogue showed excellent antithrombin activity. An X-ray co-crystal structure showed the expected interactions.
About this Structure
2BDY is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Phenolic P2/P3 core motif as thrombin inhibitors--design, synthesis, and X-ray co-crystal structure., Hanessian S, Therrien E, van Otterlo WA, Bayrakdarian M, Nilsson I, Fjellstrom O, Xue Y, Bioorg Med Chem Lett. 2006 Feb 15;16(4):1032-6. Epub 2005 Nov 15. PMID:16290930 Page seeded by OCA on Sat May 3 20:09:34 2008
