2ca7: Difference between revisions
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{{STRUCTURE_2ca7| PDB=2ca7 | SCENE= }} | |||
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'''CONKUNITZIN-S1 IS THE FIRST MEMBER OF A NEW KUNITZ-TYPE NEUROTOXIN FAMILY- STRUCTURAL AND FUNCTIONAL CHARACTERIZATION''' | '''CONKUNITZIN-S1 IS THE FIRST MEMBER OF A NEW KUNITZ-TYPE NEUROTOXIN FAMILY- STRUCTURAL AND FUNCTIONAL CHARACTERIZATION''' | ||
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[[Category: Vijayan, V.]] | [[Category: Vijayan, V.]] | ||
[[Category: Zweckstetter, M.]] | [[Category: Zweckstetter, M.]] | ||
[[Category: | [[Category: Conkunitzin]] | ||
[[Category: | [[Category: Kunitz-domain]] | ||
[[Category: | [[Category: Kunitz-type fold]] | ||
[[Category: | [[Category: Neurotoxin]] | ||
[[Category: | [[Category: Potassium channel inhibitor]] | ||
[[Category: | [[Category: Toxin]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:33:41 2008'' | |||
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Revision as of 18:33, 3 May 2008
CONKUNITZIN-S1 IS THE FIRST MEMBER OF A NEW KUNITZ-TYPE NEUROTOXIN FAMILY- STRUCTURAL AND FUNCTIONAL CHARACTERIZATION
Overview
Conkunitzin-S1 (Conk-S1) is a 60-residue neurotoxin from the venom of the cone snail Conus striatus that interacts with voltage-gated potassium channels. Conk-S1 shares sequence homology with Kunitz-type proteins but contains only two out of the three highly conserved cysteine bridges, which are typically found in these small, basic protein modules. In this study the three-dimensional structure of Conk-S1 has been solved by multidimensional NMR spectroscopy. The solution structure of recombinant Conk-S1 shows that a Kunitz fold is present, even though one of the highly conserved disulfide cross-links is missing. Introduction of a third, homologous disulfide bond into Conk-S1 results in a functional toxin with similar affinity for Shaker potassium channels. The affinity of Conk-S1 can be enhanced by a pore mutation within the Shaker channel pore indicating an interaction of Conk-S1 with the vestibule of potassium channels.
About this Structure
2CA7 is a Single protein structure of sequence from Conus striatus. Full crystallographic information is available from OCA.
Reference
Conkunitzin-S1 is the first member of a new Kunitz-type neurotoxin family. Structural and functional characterization., Bayrhuber M, Vijayan V, Ferber M, Graf R, Korukottu J, Imperial J, Garrett JE, Olivera BM, Terlau H, Zweckstetter M, Becker S, J Biol Chem. 2005 Jun 24;280(25):23766-70. Epub 2005 Apr 15. PMID:15833744 Page seeded by OCA on Sat May 3 21:33:41 2008
