2f40: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:2f40.gif|left|200px]] | [[Image:2f40.gif|left|200px]] | ||
<!-- | |||
The line below this paragraph, containing "STRUCTURE_2f40", creates the "Structure Box" on the page. | |||
You may change the PDB parameter (which sets the PDB file loaded into the applet) | |||
or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |||
| | or leave the SCENE parameter empty for the default display. | ||
| | --> | ||
{{STRUCTURE_2f40| PDB=2f40 | SCENE= }} | |||
}} | |||
'''Structure of a Novel Protein from Backbone-Centered NMR Data and NMR-Assisted Structure Prediction''' | '''Structure of a Novel Protein from Backbone-Centered NMR Data and NMR-Assisted Structure Prediction''' | ||
| Line 28: | Line 25: | ||
[[Category: Prestegard, J H.]] | [[Category: Prestegard, J H.]] | ||
[[Category: SECSG, Southeast Collaboratory for Structural Genomics.]] | [[Category: SECSG, Southeast Collaboratory for Structural Genomics.]] | ||
[[Category: | [[Category: Protein structure initiative]] | ||
[[Category: | [[Category: Protein structure prediction]] | ||
[[Category: | [[Category: Psi]] | ||
[[Category: | [[Category: Pyrococcus furious]] | ||
[[Category: | [[Category: Residual dipolar coupling]] | ||
[[Category: | [[Category: Secsg]] | ||
[[Category: | [[Category: Simulated annealing]] | ||
[[Category: | [[Category: Southeast collaboratory for structural genomic]] | ||
[[Category: | [[Category: Structural genomic]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:26:16 2008'' | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | |||
Revision as of 00:26, 4 May 2008
Structure of a Novel Protein from Backbone-Centered NMR Data and NMR-Assisted Structure Prediction
Overview
Targeting of proteins for structure determination in structural genomic programs often includes the use of threading and fold recognition methods to exclude proteins belonging to well-populated fold families, but such methods can still fail to recognize preexisting folds. The authors illustrate here a method in which limited amounts of structural data are used to improve an initial homology search and the data are subsequently used to produce a structure by data-constrained refinement of an identified structural template. The data used are primarily NMR-based residual dipolar couplings, but they also include additional chemical shift and backbone-nuclear Overhauser effect data. Using this methodology, a backbone structure was efficiently produced for a 10 kDa protein (PF1455) from Pyrococcus furiosus. Its relationship to existing structures and its probable function are discussed.
About this Structure
2F40 is a Single protein structure of sequence from Pyrococcus furiosus. Full crystallographic information is available from OCA.
Reference
Structure determination of a new protein from backbone-centered NMR data and NMR-assisted structure prediction., Mayer KL, Qu Y, Bansal S, LeBlond PD, Jenney FE Jr, Brereton PS, Adams MW, Xu Y, Prestegard JH, Proteins. 2006 Nov 1;65(2):480-9. PMID:16927360 Page seeded by OCA on Sun May 4 03:26:16 2008
Proteopedia Page Contributors and Editors (what is this?)
- Pages with broken file links
- Pyrococcus furiosus
- Single protein
- Bansal, S.
- Prestegard, J H.
- SECSG, Southeast Collaboratory for Structural Genomics.
- Protein structure initiative
- Protein structure prediction
- Psi
- Pyrococcus furious
- Residual dipolar coupling
- Secsg
- Simulated annealing
- Southeast collaboratory for structural genomic
- Structural genomic
