2gku: Difference between revisions
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'''Monomeric human telomere DNA tetraplex with 3+1 strand fold topology, two edgewise loops and double-chain reversal loop, NMR, 12 structures''' | '''Monomeric human telomere DNA tetraplex with 3+1 strand fold topology, two edgewise loops and double-chain reversal loop, NMR, 12 structures''' | ||
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==About this Structure== | ==About this Structure== | ||
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GKU OCA]. | |||
==Reference== | ==Reference== | ||
Structure of the human telomere in K+ solution: an intramolecular (3 + 1) G-quadruplex scaffold., Luu KN, Phan AT, Kuryavyi V, Lacroix L, Patel DJ, J Am Chem Soc. 2006 Aug 2;128(30):9963-70. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16866556 16866556] | Structure of the human telomere in K+ solution: an intramolecular (3 + 1) G-quadruplex scaffold., Luu KN, Phan AT, Kuryavyi V, Lacroix L, Patel DJ, J Am Chem Soc. 2006 Aug 2;128(30):9963-70. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16866556 16866556] | ||
[[Category: Kuryavyi, V V.]] | [[Category: Kuryavyi, V V.]] | ||
[[Category: Lacroix, L.]] | [[Category: Lacroix, L.]] | ||
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[[Category: Phan, A T.]] | [[Category: Phan, A T.]] | ||
[[Category: 3+1 strand folding;edgewise]] | [[Category: 3+1 strand folding;edgewise]] | ||
[[Category: | [[Category: Double-chain reversal loop]] | ||
[[Category: | [[Category: G-tetrad]] | ||
[[Category: | [[Category: Nmr,12 structure]] | ||
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Revision as of 02:13, 4 May 2008
Monomeric human telomere DNA tetraplex with 3+1 strand fold topology, two edgewise loops and double-chain reversal loop, NMR, 12 structures
Overview
We present the intramolecular G-quadruplex structure of human telomeric DNA in physiologically relevant K(+) solution. This G-quadruplex, whose (3 + 1) topology differs from folds reported previously in Na(+) solution and in a K(+)-containing crystal, involves the following: one anti.syn.syn.syn and two syn.anti.anti.anti G-tetrads; one double-chain reversal and two edgewise loops; three G-tracts oriented in one direction and the fourth in the opposite direction. The topological characteristics of this (3 + 1) G-quadruplex scaffold should provide a unique platform for structure-based anticancer drug design targeted to human telomeric DNA.
About this Structure
Full crystallographic information is available from OCA.
Reference
Structure of the human telomere in K+ solution: an intramolecular (3 + 1) G-quadruplex scaffold., Luu KN, Phan AT, Kuryavyi V, Lacroix L, Patel DJ, J Am Chem Soc. 2006 Aug 2;128(30):9963-70. PMID:16866556 Page seeded by OCA on Sun May 4 05:13:10 2008
