2il6: Difference between revisions
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'''HUMAN INTERLEUKIN-6, NMR, 32 STRUCTURES''' | '''HUMAN INTERLEUKIN-6, NMR, 32 STRUCTURES''' | ||
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[[Category: Xu, G Y.]] | [[Category: Xu, G Y.]] | ||
[[Category: Yu, H A.]] | [[Category: Yu, H A.]] | ||
[[Category: | [[Category: Cytokine]] | ||
[[Category: | [[Category: Glycoprotein]] | ||
[[Category: | [[Category: Growth factor]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:37:20 2008'' | |||
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Revision as of 04:37, 4 May 2008
HUMAN INTERLEUKIN-6, NMR, 32 STRUCTURES
Overview
Interleukin-6 (IL-6) is a 185 amino acid cytokine which exerts multiple biological effects in vivo and whose dysregulation underlies several disease processes. The solution structure of recombinant human interleukin-6 has now been determined using heteronuclear three and four-dimensional NMR spectroscopy. The structure of the molecule was determined using 3044 distance and torsion restraints derived by NMR spectroscopy to generate an ensemble of 32 structures using a combined distance geometry/simulated annealing protocol. The protein contains five alpha-helices interspersed with variable-length loops; four of these helices constitute a classical four-helix bundle with the fifth helix located in the CD loop. There were no distance violations greater than 0.3 A in any of the final 32 structures and the ensemble has an average-to-the-mean backbone root-mean-square deviation of 0.50 A for the core four-helix bundle. Although the amino-terminal 19 amino acids are disordered in solution, the remainder of the molecule has a well defined structure that shares many features displayed by other long-chain four-helix bundle cytokines. The high-resolution NMR structure of hIL-6 is used to rationalize available mutagenesis data in terms of a heteromeric receptor complex.
About this Structure
2IL6 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Solution structure of recombinant human interleukin-6., Xu GY, Yu HA, Hong J, Stahl M, McDonagh T, Kay LE, Cumming DA, J Mol Biol. 1997 May 2;268(2):468-81. PMID:9159484 Page seeded by OCA on Sun May 4 07:37:20 2008
