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'''P. AERUGINOSA FTSK MOTOR DOMAIN, HEXAMER''' | '''P. AERUGINOSA FTSK MOTOR DOMAIN, HEXAMER''' | ||
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[[Category: Sherratt, D J.]] | [[Category: Sherratt, D J.]] | ||
[[Category: Yates, J.]] | [[Category: Yates, J.]] | ||
[[Category: | [[Category: Aaa atpase]] | ||
[[Category: | [[Category: Atp-binding]] | ||
[[Category: | [[Category: Cell cycle]] | ||
[[Category: | [[Category: Cell division]] | ||
[[Category: | [[Category: Chromosome partition]] | ||
[[Category: | [[Category: Divisome]] | ||
[[Category: | [[Category: Dna translocation]] | ||
[[Category: | [[Category: Dna-binding]] | ||
[[Category: | [[Category: Hexameric ring]] | ||
[[Category: | [[Category: Inner membrane]] | ||
[[Category: | [[Category: Kop]] | ||
[[Category: | [[Category: Membrane]] | ||
[[Category: | [[Category: Membrane protein]] | ||
[[Category: | [[Category: Nucleotide-binding]] | ||
[[Category: | [[Category: Transmembrane]] | ||
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Revision as of 04:54, 4 May 2008
P. AERUGINOSA FTSK MOTOR DOMAIN, HEXAMER
Overview
FtsK is a DNA translocase that coordinates chromosome segregation and cell division in bacteria. In addition to its role as activator of XerCD site-specific recombination, FtsK can translocate double-stranded DNA (dsDNA) rapidly and directionally and reverse direction. We present crystal structures of the FtsK motor domain monomer, showing that it has a RecA-like core, the FtsK hexamer, and also showing that it is a ring with a large central annulus and a dodecamer consisting of two hexamers, head to head. Electron microscopy (EM) demonstrates the DNA-dependent existence of hexamers in solution and shows that duplex DNA passes through the middle of each ring. Comparison of FtsK monomer structures from two different crystal forms highlights a conformational change that we propose is the structural basis for a rotary inchworm mechanism of DNA translocation.
About this Structure
2IUU is a Single protein structure of sequence from Pseudomonas aeruginosa. Full crystallographic information is available from OCA.
Reference
Double-stranded DNA translocation: structure and mechanism of hexameric FtsK., Massey TH, Mercogliano CP, Yates J, Sherratt DJ, Lowe J, Mol Cell. 2006 Aug;23(4):457-69. PMID:16916635 Page seeded by OCA on Sun May 4 07:54:48 2008
Proteopedia Page Contributors and Editors (what is this?)
- Pages with broken file links
- Pseudomonas aeruginosa
- Single protein
- Lowe, J.
- Massey, T H.
- Mercogliano, C P.
- Sherratt, D J.
- Yates, J.
- Aaa atpase
- Atp-binding
- Cell cycle
- Cell division
- Chromosome partition
- Divisome
- Dna translocation
- Dna-binding
- Hexameric ring
- Inner membrane
- Kop
- Membrane
- Membrane protein
- Nucleotide-binding
- Transmembrane
