2j04: Difference between revisions
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{{STRUCTURE_2j04| PDB=2j04 | SCENE= }} | |||
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'''THE TAU60-TAU91 SUBCOMPLEX OF YEAST TRANSCRIPTION FACTOR IIIC''' | '''THE TAU60-TAU91 SUBCOMPLEX OF YEAST TRANSCRIPTION FACTOR IIIC''' | ||
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[[Category: Muller, C W.]] | [[Category: Muller, C W.]] | ||
[[Category: Mylona, A.]] | [[Category: Mylona, A.]] | ||
[[Category: | [[Category: Beta propeller]] | ||
[[Category: | [[Category: Hypothetical protein]] | ||
[[Category: | [[Category: Preinitiation complex]] | ||
[[Category: | [[Category: Transcription]] | ||
[[Category: | [[Category: Transcription factor iiic]] | ||
[[Category: | [[Category: Type 2 promoter]] | ||
[[Category: | [[Category: Yeast rna polymerase iii]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:09:01 2008'' | |||
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Revision as of 05:09, 4 May 2008
THE TAU60-TAU91 SUBCOMPLEX OF YEAST TRANSCRIPTION FACTOR IIIC
Overview
Yeast RNA polymerase III is recruited upon binding of subcomplexes tauA and tauB of transcription factor IIIC (TFIIIC) to the A and B blocks of tRNA gene promoters. The tauB subcomplex consists of subunits tau60, tau91, and tau138. We determined the 3.2 A crystal structure of tau60 bound to a large C-terminal fragment of tau91 (Deltatau91). Deltatau91 protein contains a seven-bladed propeller preceded by an N-terminal extension, whereas tau60 contains a structurally homologous propeller followed by a C-terminal domain with a novel alpha/beta fold. The two propeller domains do not have any detectable DNA binding activity and mediate heterodimer formation that may serve as scaffold for tau138 assembly. We show that the C-terminal tau60 domain interacts with the TATA binding protein (TBP). Recombinant tauB recruits TBP and stimulates TFIIIB-directed transcription on a TATA box containing tRNA gene, implying a combined contribution of tauA and tauB to preinitiation complex formation.
About this Structure
2J04 is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
Reference
Structure of the tau60/Delta tau91 subcomplex of yeast transcription factor IIIC: insights into preinitiation complex assembly., Mylona A, Fernandez-Tornero C, Legrand P, Haupt M, Sentenac A, Acker J, Muller CW, Mol Cell. 2006 Oct 20;24(2):221-32. PMID:17052456 Page seeded by OCA on Sun May 4 08:09:01 2008
