2jex: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:2jex.jpg|left|200px]] | [[Image:2jex.jpg|left|200px]] | ||
<!-- | |||
The line below this paragraph, containing "STRUCTURE_2jex", creates the "Structure Box" on the page. | |||
You may change the PDB parameter (which sets the PDB file loaded into the applet) | |||
| | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | ||
| | or leave the SCENE parameter empty for the default display. | ||
--> | |||
{{STRUCTURE_2jex| PDB=2jex | SCENE= }} | |||
}} | |||
'''TRANSCRIPTION ACTIVATOR STRUCTURE REVEALS REDOX CONTROL OF A REPLICATION INITIATION REACTION''' | '''TRANSCRIPTION ACTIVATOR STRUCTURE REVEALS REDOX CONTROL OF A REPLICATION INITIATION REACTION''' | ||
| Line 30: | Line 27: | ||
[[Category: Seavers, P R.]] | [[Category: Seavers, P R.]] | ||
[[Category: Sizov, D.]] | [[Category: Sizov, D.]] | ||
[[Category: | [[Category: Activator]] | ||
[[Category: | [[Category: Bovine papillomavirus]] | ||
[[Category: | [[Category: Dna replication]] | ||
[[Category: | [[Category: Dna-binding]] | ||
[[Category: | [[Category: E1]] | ||
[[Category: | [[Category: E2]] | ||
[[Category: | [[Category: Early protein]] | ||
[[Category: | [[Category: Nuclear protein]] | ||
[[Category: | [[Category: Oxidation]] | ||
[[Category: | [[Category: Phosphorylation]] | ||
[[Category: | [[Category: Redox control]] | ||
[[Category: | [[Category: Replication initiation]] | ||
[[Category: | [[Category: Repressor]] | ||
[[Category: | [[Category: Transcription]] | ||
[[Category: | [[Category: Transcription regulation]] | ||
[[Category: | [[Category: Viral transcription factor]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:48:25 2008'' | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | |||
Revision as of 05:48, 4 May 2008
TRANSCRIPTION ACTIVATOR STRUCTURE REVEALS REDOX CONTROL OF A REPLICATION INITIATION REACTION
Overview
Redox changes are one of the factors that influence cell-cycle progression and that control the processes of cellular proliferation, differentiation, senescence and apoptosis. Proteins regulated through redox-sensitive cysteines have been characterized but specific 'sulphydryl switches' in replication proteins remain to be identified. In bovine papillomavirus type-1, DNA replication begins when the viral transcription factor E2 recruits the viral initiator protein E1 to the origin of DNA replication (ori). Here we show that a novel dimerization interface in the E2 transcription activation domain is stabilized by a disulphide bond. Oxidative cross-linking via Cys57 sequesters the interaction surface between E1 and E2, preventing pre-initiation and replication initiation complex formation. Our data demonstrate that as well as a mechanism for regulating DNA binding, redox reactions can control replication by modulating the tertiary structure of critical protein factors using a specific redox sensor.
About this Structure
2JEX is a Single protein structure of sequence from Bovine papillomavirus type 1. Full crystallographic information is available from OCA.
Reference
Transcription activator structure reveals redox control of a replication initiation reaction., Sanders CM, Sizov D, Seavers PR, Ortiz-Lombardia M, Antson AA, Nucleic Acids Res. 2007;35(10):3504-15. Epub 2007 May 3. PMID:17478495 Page seeded by OCA on Sun May 4 08:48:25 2008
Proteopedia Page Contributors and Editors (what is this?)
- Pages with broken file links
- Bovine papillomavirus type 1
- Single protein
- Antson, A A.
- Ortiz-Lombardia, M.
- Sanders, C M.
- Seavers, P R.
- Sizov, D.
- Activator
- Bovine papillomavirus
- Dna replication
- Dna-binding
- E1
- E2
- Early protein
- Nuclear protein
- Oxidation
- Phosphorylation
- Redox control
- Replication initiation
- Repressor
- Transcription
- Transcription regulation
- Viral transcription factor
