2jgp: Difference between revisions

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[[Image:2jgp.gif|left|200px]]
[[Image:2jgp.gif|left|200px]]


{{Structure
<!--
|PDB= 2jgp |SIZE=350|CAPTION= <scene name='initialview01'>2jgp</scene>, resolution 1.85&Aring;
The line below this paragraph, containing "STRUCTURE_2jgp", creates the "Structure Box" on the page.
|SITE= <scene name='pdbsite=AC1:So4+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:So4+Binding+Site+For+Chain+A'>AC2</scene>, <scene name='pdbsite=AC3:Dio+Binding+Site+For+Chain+A'>AC3</scene>, <scene name='pdbsite=AC4:Dio+Binding+Site+For+Chain+A'>AC4</scene> and <scene name='pdbsite=AC5:Na+Binding+Site+For+Chain+A'>AC5</scene>
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|LIGAND= <scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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|ACTIVITY=  
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|GENE=  
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|DOMAIN=
{{STRUCTURE_2jgp| PDB=2jgp  | SCENE= }}  
|RELATEDENTRY=[[1dny|1DNY]]
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jgp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jgp OCA], [http://www.ebi.ac.uk/pdbsum/2jgp PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2jgp RCSB]</span>
}}


'''STRUCTURE OF THE TYCC5-6 PCP-C BIDOMAIN OF THE TYROCIDINE SYNTHETASE TYCC'''
'''STRUCTURE OF THE TYCC5-6 PCP-C BIDOMAIN OF THE TYROCIDINE SYNTHETASE TYCC'''
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[[Category: Samel, S A.]]
[[Category: Samel, S A.]]
[[Category: Schoenafinger, G.]]
[[Category: Schoenafinger, G.]]
[[Category: antibiotic biosynthesis]]
[[Category: Antibiotic biosynthesis]]
[[Category: antibiotic]]
[[Category: Antibiotic]]
[[Category: condensation domain]]
[[Category: Condensation domain]]
[[Category: ligase]]
[[Category: Ligase]]
[[Category: multifunctional enzyme]]
[[Category: Multifunctional enzyme]]
[[Category: nonribosomal peptide synthetase]]
[[Category: Nonribosomal peptide synthetase]]
[[Category: peptide bond formation]]
[[Category: Peptide bond formation]]
[[Category: peptidyl carrier domain]]
[[Category: Peptidyl carrier domain]]
[[Category: phosphopantetheine]]
[[Category: Phosphopantetheine]]
[[Category: tyrocidine]]
[[Category: Tyrocidine]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 08:53:16 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:57:59 2008''

Revision as of 05:53, 4 May 2008

File:2jgp.gif

Template:STRUCTURE 2jgp

STRUCTURE OF THE TYCC5-6 PCP-C BIDOMAIN OF THE TYROCIDINE SYNTHETASE TYCC


Overview

The crystal structure of the bidomain PCP-C from modules 5 and 6 of the nonribosomal tyrocidine synthetase TycC was determined at 1.8 A resolution. The bidomain structure reveals a V-shaped condensation domain, the canyon-like active site groove of which is associated with the preceding peptidyl carrier protein (PCP) domain at its donor side. The relative arrangement of the PCP and the peptide bond-forming condensation (C) domain places the active sites approximately 50 A apart. Accordingly, this PCP-C structure represents a conformational state prior to peptide transfer from the donor-PCP to the acceptor-PCP domain, implying the existence of additional states of PCP-C domain interaction during catalysis. Additionally, PCP-C exerts a mode of cyclization activity that mimics peptide bond formation catalyzed by C domains. Based on mutational data and pK value analysis of active site residues, it is suggested that nonribosomal peptide bond formation depends on electrostatic interactions rather than on general acid/base catalysis.

About this Structure

2JGP is a Single protein structure of sequence from Brevibacillus brevis. Full crystallographic information is available from OCA.

Reference

Structural and functional insights into a peptide bond-forming bidomain from a nonribosomal peptide synthetase., Samel SA, Schoenafinger G, Knappe TA, Marahiel MA, Essen LO, Structure. 2007 Jul;15(7):781-92. PMID:17637339 Page seeded by OCA on Sun May 4 08:53:16 2008

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