2neo: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
Line 1: Line 1:
[[Image:2neo.gif|left|200px]]
[[Image:2neo.gif|left|200px]]


{{Structure
<!--
|PDB= 2neo |SIZE=350|CAPTION= <scene name='initialview01'>2neo</scene>
The line below this paragraph, containing "STRUCTURE_2neo", creates the "Structure Box" on the page.
|SITE=
You may change the PDB parameter (which sets the PDB file loaded into the applet)
|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=NCS:SPIRO[[7-METHOXY-5-METHYL-1,2-DIHYDRO-NAPHTHALENE]-3,1&#39;-[5-HYDROXY-9-[2-METHYLAMINO-2,6-DIDEOXYGALACTOPYRANOSYL-OXY]-5-(2-OXO-[1,3]DIOXOLAN-4-YL)-3A,5,9,9A-TETRAHYDRO-3H-1-OXA-CYCLOPENTA[A]-S-INDACEN-2-ONE]]'>NCS</scene>
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
|ACTIVITY=  
or leave the SCENE parameter empty for the default display.
|GENE=  
-->
|DOMAIN=
{{STRUCTURE_2neo| PDB=2neo  | SCENE= }}  
|RELATEDENTRY=
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2neo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2neo OCA], [http://www.ebi.ac.uk/pdbsum/2neo PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2neo RCSB]</span>
}}


'''SOLUTION NMR STRUCTURE OF A TWO-BASE DNA BULGE COMPLEXED WITH AN ENEDIYNE CLEAVING ANALOG, 11 STRUCTURES'''
'''SOLUTION NMR STRUCTURE OF A TWO-BASE DNA BULGE COMPLEXED WITH AN ENEDIYNE CLEAVING ANALOG, 11 STRUCTURES'''
Line 19: Line 16:


==About this Structure==
==About this Structure==
2NEO is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. This structure supersedes the now removed PDB entry 1NEO. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NEO OCA].  
This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1neo 1neo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NEO OCA].  


==Reference==
==Reference==
Solution structure of a two-base DNA bulge complexed with an enediyne cleaving analog., Stassinopoulos A, Ji J, Gao X, Goldberg IH, Science. 1996 Jun 28;272(5270):1943-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8658168 8658168]
Solution structure of a two-base DNA bulge complexed with an enediyne cleaving analog., Stassinopoulos A, Ji J, Gao X, Goldberg IH, Science. 1996 Jun 28;272(5270):1943-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8658168 8658168]
[[Category: Protein complex]]
[[Category: Gao, X.]]
[[Category: Gao, X.]]
[[Category: Goldberg, I H.]]
[[Category: Goldberg, I H.]]
[[Category: Ji, J.]]
[[Category: Ji, J.]]
[[Category: Stassinopoulos, A.]]
[[Category: Stassinopoulos, A.]]
[[Category: bulge binding ligand]]
[[Category: Bulge binding ligand]]
[[Category: bulge dna]]
[[Category: Bulge dna]]
[[Category: carbohydrate]]
[[Category: Carbohydrate]]
[[Category: deoxyribonucleic acid]]
[[Category: Deoxyribonucleic acid]]
[[Category: dna]]
[[Category: Dna]]
[[Category: enediyne antibiotics antitumor agent]]
[[Category: Enediyne antibiotics antitumor agent]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 09:35:49 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:04:40 2008''

Revision as of 06:35, 4 May 2008

File:2neo.gif

Template:STRUCTURE 2neo

SOLUTION NMR STRUCTURE OF A TWO-BASE DNA BULGE COMPLEXED WITH AN ENEDIYNE CLEAVING ANALOG, 11 STRUCTURES


Overview

Nucleic acid bulges have been implicated in a number of biological processes and are specific cleavage targets for the enediyne antitumor antibiotic neocarzinostatin chromophore in a base-catalyzed, radical-mediated reaction. The solution structure of the complex between an analog of the bulge-specific cleaving species and an oligodeoxynucleotide containing a two-base bulge was elucidated by nuclear magnetic resonance. An unusual binding mode involves major groove recognition by the drug carbohydrate unit and tight fitting of the wedge-shaped drug in the triangular prism pocket formed by the two looped-out bulge bases and the neighboring base pairs. The two drug rings mimic helical DNA bases, complementing the bent DNA structure. The putative abstracting drug radical is 2.2 +/- 0.1 angstroms from the pro-S H5' of the target bulge nucleotide. This structure clarifies the mechanism of bulge recognition and cleavage by a drug and provides insight into the design of bulge-specific nucleic acid binding molecules.

About this Structure

This structure supersedes the now removed PDB entry 1neo. Full crystallographic information is available from OCA.

Reference

Solution structure of a two-base DNA bulge complexed with an enediyne cleaving analog., Stassinopoulos A, Ji J, Gao X, Goldberg IH, Science. 1996 Jun 28;272(5270):1943-6. PMID:8658168 Page seeded by OCA on Sun May 4 09:35:49 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=2neo&oldid=504398"