2nn6: Difference between revisions

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[[Image:2nn6.jpg|left|200px]]
[[Image:2nn6.jpg|left|200px]]


{{Structure
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The line below this paragraph, containing "STRUCTURE_2nn6", creates the "Structure Box" on the page.
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|GENE= PMSCL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), EXOSC4, RRP41, SKI6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), EXOSC8, OIP2, RRP43 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), EXOSC5, CML28, RRP46 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), EXOSC7, KIAA0116, RRP42 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), EXOSC6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), EXOSC3, RRP40 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), EXOSC2, RRP4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), EXOSC1, CSL4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
{{STRUCTURE_2nn6| PDB=2nn6  | SCENE= }}  
|RELATEDENTRY=
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nn6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nn6 OCA], [http://www.ebi.ac.uk/pdbsum/2nn6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2nn6 RCSB]</span>
}}


'''Structure of the human RNA exosome composed of Rrp41, Rrp45, Rrp46, Rrp43, Mtr3, Rrp42, Csl4, Rrp4, and Rrp40'''
'''Structure of the human RNA exosome composed of Rrp41, Rrp45, Rrp46, Rrp43, Mtr3, Rrp42, Csl4, Rrp4, and Rrp40'''
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[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Lima, C D.]]
[[Category: Lima, C D.]]
[[Category: exoribonuclease]]
[[Category: Exoribonuclease]]
[[Category: exosome]]
[[Category: Exosome]]
[[Category: phosphorolytic]]
[[Category: Phosphorolytic]]
[[Category: pm/scl]]
[[Category: Pm/scl]]
[[Category: ribonuclease]]
[[Category: Ribonuclease]]
[[Category: rna]]
[[Category: Rna]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 09:39:32 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:05:29 2008''

Revision as of 06:39, 4 May 2008

File:2nn6.jpg

Template:STRUCTURE 2nn6

Structure of the human RNA exosome composed of Rrp41, Rrp45, Rrp46, Rrp43, Mtr3, Rrp42, Csl4, Rrp4, and Rrp40


Overview

The RNA exosome is a multisubunit 3' to 5' exoribonuclease complex that participates in degradation and processing of cellular RNA. To determine the activities and structure of the eukaryotic exosome, we report the reconstitution of 9-subunit exosomes from yeast and human and reconstitution of 10- and 11-subunit exosomes from yeast. Comparative biochemical analysis between purified subunits and reconstituted exosomes using AU-rich, polyadenylated (poly[A]), generic, and structured RNA substrates reveals processive phosphorolytic activities for human Rrp41/Rrp45 and the 9-subunit human exosome, processive hydrolytic activities for yeast Rrp44 and the yeast 10-subunit exosome, distributive hydrolytic activities for Rrp6, and processive and distributive hydrolytic activities for the yeast 11-subunit exosome. To elucidate the architecture of a eukaryotic exosome, its conserved surfaces, and the structural basis for RNA decay, we report the X-ray structure determination for the 286 kDa nine-subunit human exosome at 3.35 A.

About this Structure

2NN6 is a Protein complex structure of sequences from Homo sapiens. The following page contains interesting information on the relation of 2NN6 with [Exosomes]. Full crystallographic information is available from OCA.

Reference

Reconstitution, activities, and structure of the eukaryotic RNA exosome., Liu Q, Greimann JC, Lima CD, Cell. 2006 Dec 15;127(6):1223-37. PMID:17174896 Page seeded by OCA on Sun May 4 09:39:32 2008

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