Acetylcholinesterase: Difference between revisions
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Most acetylcholinesterases have a net negative charge and a large patch of negative potential around the entrance to the active site gorge, which may be usefull to attract the positively charged acetycholine substrate to the site. As one travels down the gorge, this potential becomes increasingly more and more negative, reaching a peak at the active site at the base. Because of this potential, the peripherial site is thought to act like a substrate trap, that forces practically molecule of substrate that reaches | Most acetylcholinesterases have a net negative charge and a large patch of negative potential around the entrance to the active site gorge, which may be usefull to attract the positively charged acetycholine substrate to the site. As one travels down the gorge, this potential becomes increasingly more and more negative, reaching a peak at the active site at the base. Because of this potential, the peripherial site is thought to act like a substrate trap, that forces practically molecule of substrate that reaches | ||
the peripheral site to travel down the gorge to the active site, that probably contributes greatly to the extremely rapid rate of degrading the substrate. | the peripheral site to travel down the gorge to the active site, that probably contributes greatly to the extremely rapid rate of degrading the substrate. This whole enzyme therefore acts like a brilliantly designed natural vacuum cleaner that clears the | ||
neurotransmitter out of the synapse extremely quickly. Yet to be solved, however, is how the | |||
of | of | ||
==Selected structures== | ==Selected structures== | ||
