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[[Image:2onj.gif|left|200px]]
[[Image:2onj.gif|left|200px]]


{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2onj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2onj OCA], [http://www.ebi.ac.uk/pdbsum/2onj PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2onj RCSB]</span>
}}


'''Structure of the multidrug ABC transporter Sav1866 from S. aureus in complex with AMP-PNP'''
'''Structure of the multidrug ABC transporter Sav1866 from S. aureus in complex with AMP-PNP'''
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[[Category: Dawson, R J.P.]]
[[Category: Dawson, R J.P.]]
[[Category: Locher, K P.]]
[[Category: Locher, K P.]]
[[Category: integral membrane protein]]
[[Category: Integral membrane protein]]
[[Category: transport protein]]
[[Category: Transport protein]]
 
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:20:21 2008''

Revision as of 08:16, 4 May 2008

File:2onj.gif

Template:STRUCTURE 2onj

Structure of the multidrug ABC transporter Sav1866 from S. aureus in complex with AMP-PNP


Overview

Staphylococcus aureus Sav1866 is a bacterial homolog of the human ABC transporter Mdr1 that causes multidrug resistance in cancer cells. We report the crystal structure of Sav1866 in complex with adenosine-5'-(beta,gamma-imido)triphosphate (AMP-PNP) at 3.4A resolution and compare it with the previously determined structure of Sav1866 with bound ADP. Besides differences in the ATP-binding sites, no significant conformational changes were observed. The results confirm that the ATP-bound state of multidrug ABC transporters is coupled to an outward-facing conformation of the transmembrane domains.

About this Structure

2ONJ is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

Structure of the multidrug ABC transporter Sav1866 from Staphylococcus aureus in complex with AMP-PNP., Dawson RJ, Locher KP, FEBS Lett. 2007 Mar 6;581(5):935-8. Epub 2007 Feb 7. PMID:17303126 Page seeded by OCA on Sun May 4 11:16:21 2008

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