2oo4: Difference between revisions
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{{STRUCTURE_2oo4| PDB=2oo4 | SCENE= }} | |||
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'''Structure of LNR-HD (Negative Regulatory Region) from human Notch 2''' | '''Structure of LNR-HD (Negative Regulatory Region) from human Notch 2''' | ||
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[[Category: Sanchez-Irizarry, C.]] | [[Category: Sanchez-Irizarry, C.]] | ||
[[Category: Vardar-Ulu, D.]] | [[Category: Vardar-Ulu, D.]] | ||
[[Category: | [[Category: Alpha-beta-sandwich]] | ||
[[Category: | [[Category: Cysteine-rich]] | ||
[[Category: | [[Category: Hd domain]] | ||
[[Category: | [[Category: Lin12 notch repeat]] | ||
[[Category: | [[Category: Lnr]] | ||
[[Category: | [[Category: Sea domain]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:18:20 2008'' | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | |||
Revision as of 08:18, 4 May 2008
Structure of LNR-HD (Negative Regulatory Region) from human Notch 2
Overview
Notch receptors transmit signals between adjacent cells. Signaling is initiated when ligand binding induces metalloprotease cleavage of Notch within an extracellular negative regulatory region (NRR). We present here the X-ray structure of the human NOTCH2 NRR, which adopts an autoinhibited conformation. Extensive interdomain interactions within the NRR bury the metalloprotease site, showing that a substantial conformational movement is necessary to expose this site during activation by ligand. Leukemia-associated mutations in NOTCH1 probably release autoinhibition by destabilizing the conserved hydrophobic core of the NRR.
Disease
Known disease associated with this structure: Alagille syndrome 2 OMIM:[600275]
About this Structure
2OO4 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structural basis for autoinhibition of Notch., Gordon WR, Vardar-Ulu D, Histen G, Sanchez-Irizarry C, Aster JC, Blacklow SC, Nat Struct Mol Biol. 2007 Apr;14(4):295-300. Epub 2007 Apr 1. PMID:17401372 Page seeded by OCA on Sun May 4 11:18:20 2008
