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'''The Crystal Structure of Proprotein convertase subtilisin kexin type 9 (PCSK9)''' | '''The Crystal Structure of Proprotein convertase subtilisin kexin type 9 (PCSK9)''' | ||
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[[Category: Thibault, S T.]] | [[Category: Thibault, S T.]] | ||
[[Category: Walker, N P.C.]] | [[Category: Walker, N P.C.]] | ||
[[Category: | [[Category: Propeptide]] | ||
[[Category: | [[Category: Protease]] | ||
[[Category: | [[Category: Subtilisin]] | ||
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Revision as of 10:26, 4 May 2008
The Crystal Structure of Proprotein convertase subtilisin kexin type 9 (PCSK9)
Overview
Proprotein convertase subtilisin kexin type 9 (PCSK9) has been shown to be involved in the regulation of extracellular levels of the low-density lipoprotien receptor (LDLR). Although PCSK9 is a subtilase, it has not been shown to degrade the LDLR, and its LDLR-lowering mechanism remains uncertain. Here we report the crystal structure of human PCSK9 at 2.3 A resolution. PCSK9 has subtilisin-like pro- and catalytic domains, and the stable interaction between these domains prevents access to PCSK9's catalytic site. The C-terminal domain of PCSK9 has a novel protein fold and may mediate protein-protein interactions. The structure of PCSK9 provides insight into its biochemical characteristics and biological function.
About this Structure
2PMW is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The crystal structure of PCSK9: a regulator of plasma LDL-cholesterol., Piper DE, Jackson S, Liu Q, Romanow WG, Shetterly S, Thibault ST, Shan B, Walker NP, Structure. 2007 May;15(5):545-52. PMID:17502100 Page seeded by OCA on Sun May 4 13:26:36 2008
