2uy1: Difference between revisions
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'''CRYSTAL STRUCTURE OF CSTF-77''' | '''CRYSTAL STRUCTURE OF CSTF-77''' | ||
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[[Category: Minvielle-Sebastia, L.]] | [[Category: Minvielle-Sebastia, L.]] | ||
[[Category: Pinaud, N.]] | [[Category: Pinaud, N.]] | ||
[[Category: | [[Category: Rna-binding protein]] | ||
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Revision as of 14:46, 4 May 2008
CRYSTAL STRUCTURE OF CSTF-77
Overview
The cleavage stimulation factor (CstF) is essential for the first step of poly(A) tail formation at the 3' ends of mRNAs. This heterotrimeric complex is built around the 77-kDa protein bridging both CstF-64 and CstF-50 subunits. We have solved the crystal structure of the 77-kDa protein from Encephalitozoon cuniculi at a resolution of 2 A. The structure folds around 11 Half-a-TPR repeats defining two domains. The crystal structure reveals a tight homodimer exposing phylogenetically conserved areas for interaction with protein partners. Mapping experiments identify the C-terminal region of Rna14p, the yeast counterpart of CstF-77, as the docking domain for Rna15p, the yeast CstF-64 homologue.
About this Structure
2UY1 is a Single protein structure of sequence from Encephalitozoon cuniculi. Full crystallographic information is available from OCA.
Reference
The structure of the CstF-77 homodimer provides insights into CstF assembly., Legrand P, Pinaud N, Minvielle-Sebastia L, Fribourg S, Nucleic Acids Res. 2007;35(13):4515-22. Epub 2007 Jun 21. PMID:17584787 Page seeded by OCA on Sun May 4 17:46:54 2008
