2vg7: Difference between revisions
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{{STRUCTURE_2vg7| PDB=2vg7 | SCENE= }} | |||
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'''CRYSTAL STRUCTURES OF HIV-1 REVERSE TRANSCRIPTASE COMPLEXES WITH THIOCARBAMATE NON-NUCLEOSIDE INHIBITORS''' | '''CRYSTAL STRUCTURES OF HIV-1 REVERSE TRANSCRIPTASE COMPLEXES WITH THIOCARBAMATE NON-NUCLEOSIDE INHIBITORS''' | ||
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[[Category: Spallarossa, A.]] | [[Category: Spallarossa, A.]] | ||
[[Category: Unge, T.]] | [[Category: Unge, T.]] | ||
[[Category: | [[Category: Aid]] | ||
[[Category: | [[Category: Aspartyl protease]] | ||
[[Category: | [[Category: Capsid maturation]] | ||
[[Category: | [[Category: Core protein]] | ||
[[Category: | [[Category: Cytoplasm]] | ||
[[Category: | [[Category: Dna integration]] | ||
[[Category: | [[Category: Dna recombination]] | ||
[[Category: | [[Category: Dna-directed dna polymerase]] | ||
[[Category: | [[Category: Endonuclease]] | ||
[[Category: | [[Category: Hiv-1]] | ||
[[Category: | [[Category: Hydrolase]] | ||
[[Category: | [[Category: Lipoprotein]] | ||
[[Category: | [[Category: Magnesium]] | ||
[[Category: | [[Category: Membrane]] | ||
[[Category: | [[Category: Metal-binding]] | ||
[[Category: | [[Category: Multifunctional enzyme]] | ||
[[Category: | [[Category: Myristate]] | ||
[[Category: | [[Category: Non-nucleoside reverse transcriptase inhibitor]] | ||
[[Category: | [[Category: Nuclease]] | ||
[[Category: | [[Category: Nucleotidyltransferase]] | ||
[[Category: | [[Category: Nucleus]] | ||
[[Category: | [[Category: Phosphorylation]] | ||
[[Category: | [[Category: Protease]] | ||
[[Category: | [[Category: Reverse transcriptase]] | ||
[[Category: | [[Category: Rna-binding]] | ||
[[Category: | [[Category: Rna-directed dna polymerase]] | ||
[[Category: | [[Category: Thiocarbamate]] | ||
[[Category: | [[Category: Transferase]] | ||
[[Category: | [[Category: Viral nucleoprotein]] | ||
[[Category: | [[Category: Virion]] | ||
[[Category: | [[Category: Zinc]] | ||
[[Category: | [[Category: Zinc-finger]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 18:44:22 2008'' | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | |||
Revision as of 15:44, 4 May 2008
CRYSTAL STRUCTURES OF HIV-1 REVERSE TRANSCRIPTASE COMPLEXES WITH THIOCARBAMATE NON-NUCLEOSIDE INHIBITORS
Overview
O-Phthalimidoethyl-N-arylthiocarbamates (TCs) have been recently identified as a new class of potent HIV-1 reverse transcriptase (RT) non-nucleoside inhibitors (NNRTIs), by means of computer-aided drug design techniques [Ranise A. Spallarossa, S. Cesarini, F. Bondavalli, S. Schenone, O. Bruno, G. Menozzi, P. Fossa, L. Mosti, M. La Colla, et al., Structure-based design, parallel synthesis, structure-activity relationship, and molecular modeling studies of thiocarbamates, new potent non-nucleoside HIV-1 reverse transcriptase inhibitor isosteres of phenethylthiazolylthiourea derivatives, J. Med. Chem. 48 (2005) 3858-3873]. To elucidate the atomic details of RT/TC interaction and validate an earlier TC docking model, the structures of three RT/TC complexes were determined at 2.8-3.0A resolution by X-ray crystallography. The conformations adopted by the enzyme-bound TCs were analyzed and compared with those of bioisosterically related NNRTIs.
About this Structure
2VG7 is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.
Reference
Crystal structures of HIV-1 reverse transcriptase complexes with thiocarbamate non-nucleoside inhibitors., Spallarossa A, Cesarini S, Ranise A, Ponassi M, Unge T, Bolognesi M, Biochem Biophys Res Commun. 2008 Jan 25;365(4):764-70. Epub 2007 Nov 21. PMID:18035053 Page seeded by OCA on Sun May 4 18:44:22 2008
Proteopedia Page Contributors and Editors (what is this?)
- Pages with broken file links
- Human immunodeficiency virus 1
- Single protein
- Bolognesi, M.
- Cesarini, S.
- Ponassi, M.
- Ranise, A.
- Spallarossa, A.
- Unge, T.
- Aid
- Aspartyl protease
- Capsid maturation
- Core protein
- Cytoplasm
- Dna integration
- Dna recombination
- Dna-directed dna polymerase
- Endonuclease
- Hiv-1
- Hydrolase
- Lipoprotein
- Magnesium
- Membrane
- Metal-binding
- Multifunctional enzyme
- Myristate
- Non-nucleoside reverse transcriptase inhibitor
- Nuclease
- Nucleotidyltransferase
- Nucleus
- Phosphorylation
- Protease
- Reverse transcriptase
- Rna-binding
- Rna-directed dna polymerase
- Thiocarbamate
- Transferase
- Viral nucleoprotein
- Virion
- Zinc
- Zinc-finger
