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{{STRUCTURE_2z9g| PDB=2z9g | SCENE= }} | |||
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'''Complex structure of SARS-CoV 3C-like protease with PMA''' | '''Complex structure of SARS-CoV 3C-like protease with PMA''' | ||
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[[Category: Lee, C C.]] | [[Category: Lee, C C.]] | ||
[[Category: Wang, A H.]] | [[Category: Wang, A H.]] | ||
[[Category: | [[Category: Atp-binding]] | ||
[[Category: | [[Category: Complex]] | ||
[[Category: | [[Category: Cytoplasm]] | ||
[[Category: | [[Category: Endonuclease]] | ||
[[Category: | [[Category: Exonuclease]] | ||
[[Category: | [[Category: Helicase]] | ||
[[Category: | [[Category: Hydrolase]] | ||
[[Category: | [[Category: Membrane]] | ||
[[Category: | [[Category: Metal-binding]] | ||
[[Category: | [[Category: Nuclease]] | ||
[[Category: | [[Category: Nucleotide-binding]] | ||
[[Category: | [[Category: Nucleotidyltransferase]] | ||
[[Category: | [[Category: Protease]] | ||
[[Category: | [[Category: Ribosomal frameshift]] | ||
[[Category: | [[Category: Rna replication]] | ||
[[Category: | [[Category: Rna-binding]] | ||
[[Category: | [[Category: Rna-directed rna polymerase]] | ||
[[Category: | [[Category: Thiol protease]] | ||
[[Category: | [[Category: Transferase]] | ||
[[Category: | [[Category: Transmembrane]] | ||
[[Category: | [[Category: Zinc]] | ||
[[Category: | [[Category: Zinc-finger]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:03:55 2008'' | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | |||
Revision as of 17:03, 4 May 2008
Complex structure of SARS-CoV 3C-like protease with PMA
Overview
Five active metal-conjugated inhibitors (PMA, TDT, EPDTC, JMF1586 and JMF1600) bound with the 3C-like protease of severe acute respiratory syndrome (SARS)-associated coronavirus were analyzed crystallographically. The complex structures reveal two major inhibition modes: Hg(2+)-PMA is coordinated to C(44), M(49) and Y(54) with a square planar geometry at the S3 pocket, whereas each Zn(2+) of the four zinc-inhibitors is tetrahedrally coordinated to the H(41)-C(145) catalytic dyad. For anti-SARS drug design, this Zn(2+)-centered coordination pattern would serve as a starting platform for inhibitor optimization.
About this Structure
2Z9G is a Single protein structure of sequence from Sars coronavirus. Full crystallographic information is available from OCA.
Reference
Structural basis of mercury- and zinc-conjugated complexes as SARS-CoV 3C-like protease inhibitors., Lee CC, Kuo CJ, Hsu MF, Liang PH, Fang JM, Shie JJ, Wang AH, FEBS Lett. 2007 Nov 27;581(28):5454-8. Epub 2007 Nov 5. PMID:17981158 Page seeded by OCA on Sun May 4 20:03:55 2008
Proteopedia Page Contributors and Editors (what is this?)
- Pages with broken file links
- Sars coronavirus
- Single protein
- Lee, C C.
- Wang, A H.
- Atp-binding
- Complex
- Cytoplasm
- Endonuclease
- Exonuclease
- Helicase
- Hydrolase
- Membrane
- Metal-binding
- Nuclease
- Nucleotide-binding
- Nucleotidyltransferase
- Protease
- Ribosomal frameshift
- Rna replication
- Rna-binding
- Rna-directed rna polymerase
- Thiol protease
- Transferase
- Transmembrane
- Zinc
- Zinc-finger
