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'''THE CRYSTAL STRUCTURE OF AN RNA OLIGOMER INCORPORATING TANDEM ADENOSINE-INOSINE MISMATCHES''' | '''THE CRYSTAL STRUCTURE OF AN RNA OLIGOMER INCORPORATING TANDEM ADENOSINE-INOSINE MISMATCHES''' | ||
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==About this Structure== | ==About this Structure== | ||
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=333D OCA]. | |||
==Reference== | ==Reference== | ||
The crystal structure of an RNA oligomer incorporating tandem adenosine-inosine mismatches., Carter RJ, Baeyens KJ, SantaLucia J, Turner DH, Holbrook SR, Nucleic Acids Res. 1997 Oct 15;25(20):4117-22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9321667 9321667] | The crystal structure of an RNA oligomer incorporating tandem adenosine-inosine mismatches., Carter RJ, Baeyens KJ, SantaLucia J, Turner DH, Holbrook SR, Nucleic Acids Res. 1997 Oct 15;25(20):4117-22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9321667 9321667] | ||
[[Category: Baeyens, K J.]] | [[Category: Baeyens, K J.]] | ||
[[Category: Carter, R J.]] | [[Category: Carter, R J.]] | ||
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[[Category: Jr., J SantaLucia.]] | [[Category: Jr., J SantaLucia.]] | ||
[[Category: Turner, D H.]] | [[Category: Turner, D H.]] | ||
[[Category: | [[Category: A-rna]] | ||
[[Category: | [[Category: Double helix]] | ||
[[Category: | [[Category: Internal loop]] | ||
[[Category: | [[Category: Mismatched]] | ||
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Revision as of 17:16, 4 May 2008
THE CRYSTAL STRUCTURE OF AN RNA OLIGOMER INCORPORATING TANDEM ADENOSINE-INOSINE MISMATCHES
Overview
The X-ray crystallographic structure of the RNA duplex [r(CGCAIGCG)]2 has been refined to 2.5 A. It shows a symmetric internal loop of two non-Watson-Crick base pairs which form in the middle of the duplex. The tandem A-I/I-A pairs are related by a crystallographic two-fold axis. Both A(anti)-I(anti) mismatches are in a head-to-head conformation forming hydrogen bonds using the Watson-Crick positions. The octamer duplexes stack above one another in the cell forming a pseudo-infinite helix throughout the crystal. A hydrated calcium ion bridges between the 3'-terminal of one molecule and the backbone of another. The tandem A-I mismatches are incorporated with only minor distortion to the backbone. This is in contrast to the large helical perturbations often produced by sheared G-A pairs in RNA oligonucleotides.
About this Structure
Full crystallographic information is available from OCA.
Reference
The crystal structure of an RNA oligomer incorporating tandem adenosine-inosine mismatches., Carter RJ, Baeyens KJ, SantaLucia J, Turner DH, Holbrook SR, Nucleic Acids Res. 1997 Oct 15;25(20):4117-22. PMID:9321667 Page seeded by OCA on Sun May 4 20:16:08 2008
