3ncm: Difference between revisions
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'''NEURAL CELL ADHESION MOLECULE, MODULE 2, NMR, 20 STRUCTURES''' | '''NEURAL CELL ADHESION MOLECULE, MODULE 2, NMR, 20 STRUCTURES''' | ||
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[[Category: Soroka, V.]] | [[Category: Soroka, V.]] | ||
[[Category: Thomsen, N K.]] | [[Category: Thomsen, N K.]] | ||
[[Category: | [[Category: Cell adhesion]] | ||
[[Category: | [[Category: Glycoprotein]] | ||
[[Category: | [[Category: Gpi-anchor]] | ||
[[Category: | [[Category: Heparin-binding]] | ||
[[Category: | [[Category: Homophilic binding]] | ||
[[Category: | [[Category: Immunoglobulin fold]] | ||
[[Category: | [[Category: Neural adhesion molecule]] | ||
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Revision as of 19:07, 4 May 2008
NEURAL CELL ADHESION MOLECULE, MODULE 2, NMR, 20 STRUCTURES
Overview
The structure in solution of the second Ig-module fragment of residues 117-208 of NCAM has been determined. Like the first Ig-module of residues 20-116, it belongs to the I set of the immunogloblin superfamily. Module 1 and module 2 interact weakly, and the binding sites of this interaction have been identified. The two-module fragment NCAM(20-208) is a stable dimer. Removal of the charged residues in these sites in NCAM(20-208) abolishes the dimerization. Modeling the dimer of NCAM(20-208) to fit the interactions of these charges produces one coherent binding site for the formation of two antiparallel strands of the first two NCAM modules. This mode of binding could be a major element in trans-cellular interactions in neural cell adhesion.
About this Structure
3NCM is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
Structure and interactions of NCAM modules 1 and 2, basic elements in neural cell adhesion., Jensen PH, Soroka V, Thomsen NK, Ralets I, Berezin V, Bock E, Poulsen FM, Nat Struct Biol. 1999 May;6(5):486-93. PMID:10331878 Page seeded by OCA on Sun May 4 22:07:40 2008
