3bqq: Difference between revisions
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'''Crystal Structure of Human Saposin D (triclinic)''' | '''Crystal Structure of Human Saposin D (triclinic)''' | ||
==Overview== | |||
Saposin D is a sphingolipid activator protein required for the lysosomal breakdown of ceramide to a fatty acid and sphingosine by acid ceramidase. The crystal structure of saposin D has been determined in two different crystal forms, resulting in a total of six crystallographically independent views of this small 80-amino-acid protein. All of the structures are highly similar and reveal the monomeric form of the saposin fold previously seen in the crystal structures of saposins A and C. Saposin D is slightly more compact than the related saposins A and C owing to a slight repositioning of the ;stem' and ;hairpin' regions of the protein. | |||
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
3BQQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BQQ OCA]. | 3BQQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BQQ OCA]. | ||
==Reference== | |||
Structures of the human ceramide activator protein saposin D., Popovic K, Prive GG, Acta Crystallogr D Biol Crystallogr. 2008 May;64(Pt 5):589-94. Epub 2008, Apr 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18453694 18453694] | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Popovic, K.]] | [[Category: Popovic, K.]] | ||
[[Category: Prive, G G.]] | [[Category: Prive, G G.]] | ||
[[Category: Acid ceramidase | [[Category: Acid ceramidase]] | ||
[[Category: Farber disease]] | |||
[[Category: Lipid binding protein]] | [[Category: Lipid binding protein]] | ||
[[Category: Lipid metabolism]] | [[Category: Lipid metabolism]] | ||
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[[Category: Sphingolipid activator protein]] | [[Category: Sphingolipid activator protein]] | ||
[[Category: Sphingolipid metabolism]] | [[Category: Sphingolipid metabolism]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu May 22 22:35:30 2008'' | ||
