Acid-beta-glucosidase: Difference between revisions

Revision as of 06:32, 3 June 2008 view source Boris Brumshtein (talk \| contribs) 64 edits No edit summary ← Older edit		Revision as of 06:54, 3 June 2008 view source Boris Brumshtein (talk \| contribs) 64 edits No edit summary Newer edit →
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	==Cerezyme™ vs Plant produced enzyme in a Gaucher disease==		==Cerezyme™ vs Plant produced enzyme in a Gaucher disease==

	Acid-beta-glucosidase for treatment of a Gaucher disease is produced in CHO cells (Cerezyme™) ([[1ogs]];[[1y7v]];[[2f61]]; [[2nt0]]; [[2nt1]]; [[2v3d]]; [[2v3e]]; [[2nsx]]; [[2j25]]) or in a carrot stem cells suspension (plant produced enzyme by Protalix biopharmaceuticals, [[2v3d]]; [[2v3f]]; [[2v3e]]). Recently solved structures of both enzymes indicate the enzymes are virtually identical in their 3D structures. Yet some small insignificant differences in sugars arise due to the use of different expression systems.		Acid-beta-glucosidase for treatment of a Gaucher disease is produced in CHO cells (Cerezyme™) ([[1ogs]];[[1y7v]];[[2f61]]; [[2nt0]]; [[2nt1]]; [[2v3d]]; [[2v3e]]; [[2nsx]]; [[2j25]]) or in a carrot stem cells suspension (plant produced enzyme by Protalix biopharmaceuticals, [[2v3d]]; [[2v3f]]; [[2v3e]]). Recently solved structures of both enzymes indicate the enzymes are virtually <scene name='Acid-beta-glucosidase/Overlay/1'>identical </scene>in their 3D structures. Yet some small insignificant differences in sugars arise due to the use of different expression systems.

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