1c7d: Difference between revisions

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[[Image:1c7d.gif|left|200px]]
[[Image:1c7d.png|left|200px]]


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==Overview==
{{ABSTRACT_10930828}}
The crystal structures of three recombinant human hemoglobins, rHb1. 0, rHb1.1 and rHb1.2, have been determined in the deoxy state at 1.8 A resolution. Two of the three proteins, rHb1.1 and rHb1.2, contain a genetic fusion of the alpha subunits, a one- or two-glycine link, respectively, whereas rHb1.0 does not. The glycine crosslinks, localized between one N- and C--termini pair of the alpha subunits in the deoxy crystalline state, do not perturb the overall tertiary or quaternary or even the local structure of hemoglobin. Therefore, genetic fusion to prevent the dissociation of the hemoglobin tetramer, thereby inhibiting renal clearance based upon molecular size, is a structurally conservative method to stabilize hemoglobin for use as an oxygen-delivery therapeutic.


==About this Structure==
==About this Structure==
1C7D is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1C7D with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb41_1.html Hemoglobin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C7D OCA].  
1C7D is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1C7D with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb41_1.html Hemoglobin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C7D OCA].  
==Reference==
Genetically crosslinked hemoglobin: a structural study., Brucker EA, Acta Crystallogr D Biol Crystallogr. 2000 Jul;56(Pt 7):812-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10930828 10930828]
[[Category: Hemoglobin]]
[[Category: Hemoglobin]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Heme]]
[[Category: Heme]]
[[Category: Oxygen delivery vehicle]]
[[Category: Oxygen delivery vehicle]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 12:25:04 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:06:40 2008''

Revision as of 14:06, 26 June 2008

File:1c7d.png

Template:STRUCTURE 1c7d

DEOXY RHB1.2 (RECOMBINANT HEMOGLOBIN)


Template:ABSTRACT 10930828

About this Structure

1C7D is a Protein complex structure of sequences from Homo sapiens. The following page contains interesting information on the relation of 1C7D with [Hemoglobin]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:06:40 2008

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