1cos: Difference between revisions

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[[Image:1cos.jpg|left|200px]]
[[Image:1cos.png|left|200px]]


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==Overview==
{{ABSTRACT_8446897}}
The x-ray crystal structure of a peptide designed to form a double-stranded parallel coiled coil shows that it is actually a triple-stranded coiled coil formed by three alpha-helices. Unlike the designed parallel coiled coil, the helices run up-up-down. The structure is stabilized by a distinctive hydrophobic interface consisting of eight layers. As in the design, each alpha-helix in the coiled coil contributes one leucine side chain to each layer. The structure suggests that hydrophobic interactions are a dominant factor in the stabilization of coiled coils. The stoichiometry and geometry of coiled coils are primarily determined by side chain packing in the solvent-inaccessible interior, but electrostatic interactions also contribute.


==About this Structure==
==About this Structure==
The following page contains interesting information on the relation of 1COS with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb70_1.html Designer Proteins]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1COS OCA].  
The following page contains interesting information on the relation of 1COS with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb70_1.html Designer Proteins]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1COS OCA].  
==Reference==
Crystal structure of a synthetic triple-stranded alpha-helical bundle., Lovejoy B, Choe S, Cascio D, McRorie DK, DeGrado WF, Eisenberg D, Science. 1993 Feb 26;259(5099):1288-93. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8446897 8446897]
[[Category: Designer Proteins]]
[[Category: Designer Proteins]]
[[Category: Cascio, D.]]
[[Category: Cascio, D.]]
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[[Category: Mcrorie, D K.]]
[[Category: Mcrorie, D K.]]
[[Category: Alpha-helical bundle]]
[[Category: Alpha-helical bundle]]
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