1fkn: Difference between revisions

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[[Image:1fkn.gif|left|200px]]
[[Image:1fkn.png|left|200px]]


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==Overview==
{{ABSTRACT_11021803}}
Memapsin 2 (beta-secretase) is a membrane-associated aspartic protease involved in the production of beta-amyloid peptide in Alzheimer's disease and is a major target for drug design. We determined the crystal structure of the protease domain of human memapsin 2 complexed to an eight-residue inhibitor at 1.9 angstrom resolution. The active site of memapsin 2 is more open and less hydrophobic than that of other human aspartic proteases. The subsite locations from S4 to S2' are well defined. A kink of the inhibitor chain at P2' and the change of chain direction of P3' and P4' may be mimicked to provide inhibitor selectivity.


==About this Structure==
==About this Structure==
1FKN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1FKN with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb79_1.html Amyloid-beta Precursor Protein]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FKN OCA].  
1FKN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1FKN with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb79_1.html Amyloid-beta Precursor Protein]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FKN OCA].  
==Reference==
Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor., Hong L, Koelsch G, Lin X, Wu S, Terzyan S, Ghosh AK, Zhang XC, Tang J, Science. 2000 Oct 6;290(5489):150-3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11021803 11021803]
[[Category: Amyloid-beta Precursor Protein]]
[[Category: Amyloid-beta Precursor Protein]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Beta-secretase]]
[[Category: Beta-secretase]]
[[Category: Memapsin 2]]
[[Category: Memapsin 2]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 16:26:16 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:21:55 2008''

Revision as of 14:21, 26 June 2008

File:1fkn.png


Drag the structure with the mouse to rotate
1fkn, resolution 1.90Å (default scene)
Non-Standard Residues: 1OL
Activity: Memapsin 2, with EC number 3.4.23.46
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



STRUCTURE OF BETA-SECRETASE COMPLEXED WITH INHIBITOR


Template:ABSTRACT 11021803

About this Structure

1FKN is a Single protein structure of sequence from Homo sapiens. The following page contains interesting information on the relation of 1FKN with [Amyloid-beta Precursor Protein]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:21:55 2008

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