1h02: Difference between revisions

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[[Image:1h02.gif|left|200px]]
[[Image:1h02.png|left|200px]]


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==Overview==
{{ABSTRACT_12135360}}
Human insulin-like growth factors I and II (hIGF-I, hIGF-II) are potent stimulators of cell and growth processes. They display high sequence similarity to both the A and B chains of insulin but contain an additional connecting C-domain, which reflects their secretion without specific packaging or precursor conversion. IGFs also have an extension at the C-terminus known as the D-domain. This paper describes four homologous hIGF-1 structures, obtained from crystals grown in the presence of the detergent SB12, which reveal additional detail in the C- and D-domains. Two different detergent binding modes observed in the crystals may reflect different hIGF-I biological properties such as the interaction with IGF binding proteins and self-aggregation. While the helical core of hIGF-I is very similar to that in insulin, there are distinct differences in the region of hIGF-I corresponding to the insulin B chain C-terminus, residues B25-B30. In hIGF-I, these residues (24-29) and the following C-domain form an extensive loop protruding 20 A from the core, which results in a substantially different conformation for the receptor binding epitope in hIGF-I compared to insulin. One notable feature of the structures presented here is demonstration of peptide-bond cleavage between Ser35 and Arg36 resulting in an apparent gap between residues 35 and 39. The equivalent region of proinsulin is involved in hormone processing demanding a reassessment of the structural integrity of hIGF-I in relation to its biological function.


==About this Structure==
==About this Structure==
1H02 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1H02 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb52_1.html Growth Hormone]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H02 OCA].  
1H02 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1H02 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb52_1.html Growth Hormone]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H02 OCA].  
==Reference==
Structural origins of the functional divergence of human insulin-like growth factor-I and insulin., Brzozowski AM, Dodson EJ, Dodson GG, Murshudov GN, Verma C, Turkenburg JP, de Bree FM, Dauter Z, Biochemistry. 2002 Jul 30;41(30):9389-97. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12135360 12135360]
[[Category: Growth Hormone]]
[[Category: Growth Hormone]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Insulin family]]
[[Category: Insulin family]]
[[Category: Plasma]]
[[Category: Plasma]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 18:14:23 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:26:55 2008''

Revision as of 14:26, 26 June 2008

File:1h02.png

Template:STRUCTURE 1h02

HUMAN INSULIN-LIKE GROWTH FACTOR; SRS DARESBURY DATA


Template:ABSTRACT 12135360

About this Structure

1H02 is a Single protein structure of sequence from Homo sapiens. The following page contains interesting information on the relation of 1H02 with [Growth Hormone]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:26:55 2008

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