1l2y: Difference between revisions

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[[Image:1l2y.gif|left|200px]]
[[Image:1l2y.png|left|200px]]


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==Overview==
{{ABSTRACT_11979279}}
Truncation and mutation of a poorly folded 39-residue peptide has produced 20-residue constructs that are &gt;95% folded in water at physiological pH. These constructs optimize a novel fold, designated as the 'Trp-cage' motif, and are significantly more stable than any other miniprotein reported to date. Folding is cooperative and hydrophobically driven by the encapsulation of a Trp side chain in a sheath of Pro rings. As the smallest protein-like construct, Trp-cage miniproteins should provide a testing ground for both experimental studies and computational simulations of protein folding and unfolding pathways. Pro Trp interactions may be a particularly effective strategy for the a priori design of self-folding peptides.


==About this Structure==
==About this Structure==
The following page contains interesting information on the relation of 1L2Y with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb70_1.html Designer Proteins]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2Y OCA].  
The following page contains interesting information on the relation of 1L2Y with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb70_1.html Designer Proteins]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2Y OCA].  
==Reference==
Designing a 20-residue protein., Neidigh JW, Fesinmeyer RM, Andersen NH, Nat Struct Biol. 2002 Jun;9(6):425-30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11979279 11979279]
[[Category: Designer Proteins]]
[[Category: Designer Proteins]]
[[Category: Andersen, N H.]]
[[Category: Andersen, N H.]]
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[[Category: Trp-cage]]
[[Category: Trp-cage]]
[[Category: Two-state folding]]
[[Category: Two-state folding]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 23:28:53 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:40:01 2008''

Revision as of 14:40, 26 June 2008

File:1l2y.png

Template:STRUCTURE 1l2y

NMR Structure of Trp-Cage Miniprotein Construct TC5b


Template:ABSTRACT 11979279

About this Structure

The following page contains interesting information on the relation of 1L2Y with [Designer Proteins]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:40:01 2008

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