1prh: Difference between revisions

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[[Image:1prh.gif|left|200px]]
[[Image:1prh.png|left|200px]]


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==Overview==
{{ABSTRACT_8121489}}
The three-dimensional structure of prostaglandin H2 synthase-1, an integral membrane protein, has been determined at 3.5 A resolution by X-ray crystallography. This bifunctional enzyme comprises three independent folding units: an epidermal growth factor domain, a membrane-binding motif and an enzymatic domain. Two adjacent but spatially distinct active sites were found for its haem-dependent peroxidase and cyclooxygenase activities. The cyclooxygenase active site is created by a long, hydrophobic channel that is the site of non-steroidal anti-inflammatory drug binding. The conformation of the membrane-binding motif strongly suggests that the enzyme integrates into only one leaflet of the lipid bilayer and is thus a monotopic membrane protein.


==About this Structure==
==About this Structure==
1PRH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Ovis_aries Ovis aries]. The following page contains interesting information on the relation of 1PRH with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb17_1.html Cyclooxygenase]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PRH OCA].  
1PRH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Ovis_aries Ovis aries]. The following page contains interesting information on the relation of 1PRH with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb17_1.html Cyclooxygenase]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PRH OCA].  
==Reference==
The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1., Picot D, Loll PJ, Garavito RM, Nature. 1994 Jan 20;367(6460):243-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8121489 8121489]
[[Category: Cyclooxygenase]]
[[Category: Cyclooxygenase]]
[[Category: Ovis aries]]
[[Category: Ovis aries]]
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[[Category: Loll, P J.]]
[[Category: Loll, P J.]]
[[Category: Picot, D.]]
[[Category: Picot, D.]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 05:24:23 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:49:55 2008''

Revision as of 14:49, 26 June 2008

File:1prh.png


Drag the structure with the mouse to rotate
1prh, resolution 3.50Å (default scene)
Ligands: HEM
Activity: Prostaglandin-endoperoxide synthase, with EC number 1.14.99.1
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



THE X-RAY CRYSTAL STRUCTURE OF THE MEMBRANE PROTEIN PROSTAGLANDIN H2 SYNTHASE-1


Template:ABSTRACT 8121489

About this Structure

1PRH is a Single protein structure of sequence from Ovis aries. The following page contains interesting information on the relation of 1PRH with [Cyclooxygenase]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:49:55 2008

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