1q5a: Difference between revisions

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[[Image:1q5a.~~gif~~|left|200px]]

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~~==Overview==~~

Cell adhesion by adherens junctions and desmosomes relies on interactions between cadherin molecules. However, the molecular interfaces that define molecular specificity and that mediate adhesion remain controversial. We used electron tomography of plastic sections from neonatal mouse skin to visualize the organization of desmosomes in situ. The resulting three-dimensional maps reveal individual cadherin molecules forming discrete groups and interacting through their tips. Fitting of an x-ray crystal structure for C-cadherin to these maps is consistent with a flexible intermolecular interface mediated by an exchange of amino-terminal tryptophans. This flexibility suggests a novel mechanism for generating both cis and trans interactions and for propagating these adhesive interactions along the junction.

==About this Structure==

Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q5A OCA].

~~==Reference==~~

~~Untangling desmosomal knots with electron tomography., He W, Cowin P, Stokes DL, Science. 2003 Oct 3;302(5642):109-13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14526082 14526082]~~

[[Category: Cowin, P.]]

[[Category: He, W.]]

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[[Category: Junction]]

[[Category: Trans interaction]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 05~~:52:46 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:51:04 2008''

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-[[Image:1q5a.gif|left|200px]]
+[[Image:1q5a.png|left|200px]]
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-==Overview==
+{{ABSTRACT_14526082}}
-Cell adhesion by adherens junctions and desmosomes relies on interactions between cadherin molecules. However, the molecular interfaces that define molecular specificity and that mediate adhesion remain controversial. We used electron tomography of plastic sections from neonatal mouse skin to visualize the organization of desmosomes in situ. The resulting three-dimensional maps reveal individual cadherin molecules forming discrete groups and interacting through their tips. Fitting of an x-ray crystal structure for C-cadherin to these maps is consistent with a flexible intermolecular interface mediated by an exchange of amino-terminal tryptophans. This flexibility suggests a novel mechanism for generating both cis and trans interactions and for propagating these adhesive interactions along the junction.
 ==About this Structure==
 Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q5A OCA].
-==Reference==
-Untangling desmosomal knots with electron tomography., He W, Cowin P, Stokes DL, Science. 2003 Oct 3;302(5642):109-13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14526082 14526082]
 [[Category: Cowin, P.]]
 [[Category: He, W.]]
@@ Line 28: / Line 24: @@
 [[Category: Junction]]
 [[Category: Trans interaction]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 05:52:46 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:51:04 2008''