1sg1: Difference between revisions

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[[Image:1sg1.~~gif~~|left|200px]]

[[Image:1sg1.png|left|200px]]

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~~==Overview==~~

Neurotrophins are secreted growth factors critical for the development and maintenance of the vertebrate nervous system. Neurotrophins activate two types of cell surface receptors, the Trk receptor tyrosine kinases and the shared p75 neurotrophin receptor. We have determined the 2.4 A crystal structure of the prototypic neurotrophin, nerve growth factor (NGF), complexed with the extracellular domain of p75. Surprisingly, the complex is composed of an NGF homodimer asymmetrically bound to a single p75. p75 binds along the homodimeric interface of NGF, which disables NGF's symmetry-related second p75 binding site through an allosteric conformational change. Thus, neurotrophin signaling through p75 may occur by disassembly of p75 dimers and assembly of asymmetric 2:1 neurotrophin/p75 complexes, which could potentially engage a Trk receptor to form a trimolecular signaling complex.

==Disease==

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==About this Structure==

1SG1 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. The following page contains interesting information on the relation of 1SG1 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb68_1.html Neurotrophins]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SG1 OCA].

~~==Reference==~~

Structure of nerve growth factor complexed with the shared neurotrophin receptor p75., He XL, Garcia KC, Science. 2004 May 7;304(5672):870-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15131306 15131306]

[[Category: Homo sapiens]]

[[Category: Neurotrophins]]

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[[Category: P75]]

[[Category: Receptor/ligand complex]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 08~~:39:23 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:57:11 2008''

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-[[Image:1sg1.gif|left|200px]]
+[[Image:1sg1.png|left|200px]]
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-==Overview==
+{{ABSTRACT_15131306}}
-Neurotrophins are secreted growth factors critical for the development and maintenance of the vertebrate nervous system. Neurotrophins activate two types of cell surface receptors, the Trk receptor tyrosine kinases and the shared p75 neurotrophin receptor. We have determined the 2.4 A crystal structure of the prototypic neurotrophin, nerve growth factor (NGF), complexed with the extracellular domain of p75. Surprisingly, the complex is composed of an NGF homodimer asymmetrically bound to a single p75. p75 binds along the homodimeric interface of NGF, which disables NGF's symmetry-related second p75 binding site through an allosteric conformational change. Thus, neurotrophin signaling through p75 may occur by disassembly of p75 dimers and assembly of asymmetric 2:1 neurotrophin/p75 complexes, which could potentially engage a Trk receptor to form a trimolecular signaling complex.
 ==Disease==
@@ Line 20: / Line 19: @@
 ==About this Structure==
 SG1 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. The following page contains interesting information on the relation of 1SG1 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb68_1.html Neurotrophins]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SG1 OCA].
-==Reference==
-Structure of nerve growth factor complexed with the shared neurotrophin receptor p75., He XL, Garcia KC, Science. 2004 May 7;304(5672):870-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15131306 15131306]
 [[Category: Homo sapiens]]
 [[Category: Neurotrophins]]
@@ Line 37: / Line 33: @@
 [[Category: P75]]
 [[Category: Receptor/ligand complex]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 08:39:23 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:57:11 2008''