1tbd: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
Line 1: Line 1:
[[Image:1tbd.gif|left|200px]]
[[Image:1tbd.png|left|200px]]


<!--
<!--
Line 12: Line 12:




==Overview==
{{ABSTRACT_8946857}}
The structure of the domain from simian virus 40 (SV40) large T-antigen that binds to the SV40 origin of DNA replication (T-ag-OBD131-260) has been determined by nuclear magnetic resonance spectroscopy. The overall fold, consisting of a central five-stranded antiparallel beta-sheet flanked by two alpha-helices on one side and one alpha-helix and one 3(10)-helix on the other, is a new one. Previous mutational analyses have identified two elements, termed A (approximately 152-155) and B2 (203-207), as essential for origin-specific recognition. These elements form two closely juxtaposed loops that define a continuous surface on the protein. The addition of a duplex oligonucleotide containing the origin recognition pentanucleotide GAGGC induces chemical shift changes and slows amide proton exchange in resonances from this region, indicating that this surface directly contacts the DNA.


==About this Structure==
==About this Structure==
1TBD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Simian_virus_40 Simian virus 40]. The following page contains interesting information on the relation of 1TBD with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb47_1.html Simian Virus 40]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TBD OCA].  
1TBD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Simian_virus_40 Simian virus 40]. The following page contains interesting information on the relation of 1TBD with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb47_1.html Simian Virus 40]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TBD OCA].  
==Reference==
Solution structure of the origin DNA-binding domain of SV40 T-antigen., Luo X, Sanford DG, Bullock PA, Bachovchin WW, Nat Struct Biol. 1996 Dec;3(12):1034-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8946857 8946857]
[[Category: Simian Virus 40]]
[[Category: Simian Virus 40]]
[[Category: Simian virus 40]]
[[Category: Simian virus 40]]
Line 29: Line 25:
[[Category: Dna-binding protein]]
[[Category: Dna-binding protein]]
[[Category: Replication origin binding domain]]
[[Category: Replication origin binding domain]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 09:45:53 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:59:48 2008''

Revision as of 14:59, 26 June 2008

File:1tbd.png

Template:STRUCTURE 1tbd

SOLUTION STRUCTURE OF THE ORIGIN DNA BINDING DOMAIN OF SV40 T-ANTIGEN, NMR, MINIMIZED AVERAGE STRUCTURE


Template:ABSTRACT 8946857

About this Structure

1TBD is a Single protein structure of sequence from Simian virus 40. The following page contains interesting information on the relation of 1TBD with [Simian Virus 40]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:59:48 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=1tbd&oldid=568146"