1tgh: Difference between revisions

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[[Image:1tgh.~~gif~~|left|200px]]

[[Image:1tgh.png|left|200px]]

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~~==Overview==~~

The crystal structure of a complex of human TATA-binding protein with TATA-sequence DNA has been solved, complementing earlier TBP/DNA analyses from Saccharomyces cerevisiae and Arabidopsis thaliana. Special insight into TATA box specificity is provided by considering the TBP/DNA complex, not as a protein molecule with bound DNA, but as a DNA duplex with a particularly large minor groove ligand. This point of view provides explanations for: (1) why T.A base-pairs are required rather than C.G; (2) why an alternation of T and A bases is needed; (3) how TBP recognizes the upstream and downstream ends of the TATA box in order to bind properly; and (4) why the second half of the TATA box can be more variable than the first.

==Disease==

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==About this Structure==

1TGH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1TGH with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb67_1.html TATA-Binding Protein]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TGH OCA].

~~==Reference==~~

~~How proteins recognize the TATA box., Juo ZS, Chiu TK, Leiberman PM, Baikalov I, Berk AJ, Dickerson RE, J Mol Biol. 1996 Aug 16;261(2):239-54. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8757291 8757291]~~

[[Category: Homo sapiens]]

[[Category: Single protein]]

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[[Category: Dna binding protein]]

[[Category: Transcription factor]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 18:00:43 2008''

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-[[Image:1tgh.gif|left|200px]]
+[[Image:1tgh.png|left|200px]]
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-==Overview==
+{{ABSTRACT_8757291}}
-The crystal structure of a complex of human TATA-binding protein with TATA-sequence DNA has been solved, complementing earlier TBP/DNA analyses from Saccharomyces cerevisiae and Arabidopsis thaliana. Special insight into TATA box specificity is provided by considering the TBP/DNA complex, not as a protein molecule with bound DNA, but as a DNA duplex with a particularly large minor groove ligand. This point of view provides explanations for: (1) why T.A base-pairs are required rather than C.G; (2) why an alternation of T and A bases is needed; (3) how TBP recognizes the upstream and downstream ends of the TATA box in order to bind properly; and (4) why the second half of the TATA box can be more variable than the first.
 ==Disease==
@@ Line 20: / Line 19: @@
 ==About this Structure==
 TGH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1TGH with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb67_1.html TATA-Binding Protein]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TGH OCA].
-==Reference==
-How proteins recognize the TATA box., Juo ZS, Chiu TK, Leiberman PM, Baikalov I, Berk AJ, Dickerson RE, J Mol Biol. 1996 Aug 16;261(2):239-54. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8757291 8757291]
 [[Category: Homo sapiens]]
 [[Category: Single protein]]
@@ Line 31: / Line 27: @@
 [[Category: Dna binding protein]]
 [[Category: Transcription factor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 24 09:39:55 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 18:00:43 2008''