1ytb: Difference between revisions

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[[Image:1ytb.jpg|left|200px]]
[[Image:1ytb.png|left|200px]]


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==Overview==
{{ABSTRACT_8413604}}
The 2.5 A crystal structure of a TATA-box complex with yeast TBP shows that the eight base pairs of the TATA box bind to the concave surface of TBP by bending towards the major groove with unprecedented severity. This produces a wide open, underwound, shallow minor groove which forms a primarily hydrophobic interface with the entire under-surface of the TBP saddle. The severe bend and a positive writhe radically alter the trajectory of the flanking B-form DNA.


==About this Structure==
==About this Structure==
1YTB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. The following page contains interesting information on the relation of 1YTB with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb67_1.html TATA-Binding Protein]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YTB OCA].  
1YTB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. The following page contains interesting information on the relation of 1YTB with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb67_1.html TATA-Binding Protein]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YTB OCA].  
==Reference==
Crystal structure of a yeast TBP/TATA-box complex., Kim Y, Geiger JH, Hahn S, Sigler PB, Nature. 1993 Oct 7;365(6446):512-20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8413604 8413604]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Sigler, P B.]]
[[Category: Sigler, P B.]]
[[Category: Protein-dna complex]]
[[Category: Protein-dna complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 24 09:39:47 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 18:09:04 2008''

Revision as of 15:09, 26 June 2008

File:1ytb.png

Template:STRUCTURE 1ytb

CRYSTAL STRUCTURE OF A YEAST TBP/TATA-BOX COMPLEX


Template:ABSTRACT 8413604

About this Structure

1YTB is a Single protein structure of sequence from Saccharomyces cerevisiae. The following page contains interesting information on the relation of 1YTB with [TATA-Binding Protein]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 18:09:04 2008

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