3cln: Difference between revisions

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[[Image:3cln.gif|left|200px]]
[[Image:3cln.png|left|200px]]


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==Overview==
{{ABSTRACT_3145979}}
The crystal structure of mammalian calmodulin has been refined at 2.2 A (1 A = 0.1 nm) resolution using a restrained least-squares method. The final crystallographic R-factor, based on 6685 reflections in the range 2.2 A less than or equal to d less than or equal to 5.0 A with intensities exceeding 2.5 sigma, is 0.175. Bond lengths and bond angles in the molecule have root-mean-square deviations from ideal values of 0.016 A and 1.7 degrees, respectively. The refined model includes residues 5 to 147, four Ca2+ and 69 water molecules per molecule of calmodulin. The electron density for residues 1 to 4 and 148 is poorly defined, and they are not included in the model. The molecule is shaped somewhat like a dumbbell, with an overall length of 65 A; the two lobes are connected by a seven-turn alpha-helix. Prominent secondary structural features include seven alpha-helices, four Ca2+-binding loops, and two short, double-stranded antiparallel beta-sheets between pairs of adjacent Ca2+-binding loops. The four Ca2+-binding domains in calmodulin have a typical EF hand conformation (helix-loop-helix) and are similar to those described in other Ca2+-binding proteins. The X-ray structure determination of calmodulin shows a large hydrophobic cleft in each half of the molecule. These hydrophobic regions probably represent the sites of interaction with many of the pharmacological agents known to bind to calmodulin.


==About this Structure==
==About this Structure==
3CLN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1cln 1cln]. The following page contains interesting information on the relation of 3CLN with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb44_1.html Calmodulin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CLN OCA].  
3CLN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1cln 1cln]. The following page contains interesting information on the relation of 3CLN with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb44_1.html Calmodulin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CLN OCA].  
==Reference==
Structure of calmodulin refined at 2.2 A resolution., Babu YS, Bugg CE, Cook WJ, J Mol Biol. 1988 Nov 5;204(1):191-204. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/3145979 3145979]
[[Category: Calmodulin]]
[[Category: Calmodulin]]
[[Category: Rattus rattus]]
[[Category: Rattus rattus]]
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[[Category: Cook, W J.]]
[[Category: Cook, W J.]]
[[Category: Calcium binding protein]]
[[Category: Calcium binding protein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 21:53:02 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 18:25:29 2008''

Revision as of 15:25, 26 June 2008


Drag the structure with the mouse to rotate
3cln, resolution 2.20Å (default scene)
Ligands: CA
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



STRUCTURE OF CALMODULIN REFINED AT 2.2 ANGSTROMS RESOLUTION


Template:ABSTRACT 3145979

About this Structure

3CLN is a Single protein structure of sequence from Rattus rattus. This structure supersedes the now removed PDB entry 1cln. The following page contains interesting information on the relation of 3CLN with [Calmodulin]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 18:25:29 2008

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