1k9v: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,843 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,843 edits
No edit summary
Line 1: Line 1:
[[Image:1k9v.jpg|left|200px]]
[[Image:1k9v.png|left|200px]]


<!--
<!--
Line 12: Line 12:




==Overview==
{{ABSTRACT_11839304}}
Since reactive ammonia is not available under physiological conditions, glutamine is used as a source for the incorporation of nitrogen in a number of metabolic pathway intermediates. The heterodimeric ImGP synthase that links histidine and purine biosynthesis belongs to the family of glutamine amidotransferases in which the glutaminase activity is coupled with a subsequent synthase activity specific for each member of the enzyme family. Its X-ray structure from the hyperthermophile Thermotoga maritima shows that the glutaminase subunit is associated with the N-terminal face of the (beta alpha)(8) barrel cyclase subunit. The complex reveals a putative tunnel for the transfer of ammonia over a distance of 25 A. Although ammonia tunneling has been reported for glutamine amidotransferases, the ImGP synthase has evolved a novel mechanism, which extends the known functional properties of the versatile (beta alpha)(8) barrel fold.


==About this Structure==
==About this Structure==
1K9V is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K9V OCA].  
1K9V is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K9V OCA].  
==Reference==
Structural evidence for ammonia tunneling across the (beta alpha)(8) barrel of the imidazole glycerol phosphate synthase bienzyme complex., Douangamath A, Walker M, Beismann-Driemeyer S, Vega-Fernandez MC, Sterner R, Wilmanns M, Structure. 2002 Feb;10(2):185-93. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11839304 11839304]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Thermotoga maritima]]
[[Category: Thermotoga maritima]]
Line 32: Line 28:
[[Category: Imidazole glycerol phosphate synthase]]
[[Category: Imidazole glycerol phosphate synthase]]
[[Category: X-ray structure]]
[[Category: X-ray structure]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 22:29:06 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Jun 27 00:52:04 2008''

Revision as of 21:52, 26 June 2008

File:1k9v.png

Template:STRUCTURE 1k9v

Structural evidence for ammonia tunelling across the (beta-alpha)8-barrel of the imidazole glycerol phosphate synthase bienzyme complex


Template:ABSTRACT 11839304

About this Structure

1K9V is a Single protein structure of sequence from Thermotoga maritima. Full crystallographic information is available from OCA.

Page seeded by OCA on Fri Jun 27 00:52:04 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=1k9v&oldid=569032"