178d: Difference between revisions

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[[Image:178d.~~gif~~|left|200px]]

[[Image:178d.png|left|200px]]

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~~'''~~CRYSTAL STRUCTURE OF A DNA DUPLEX CONTAINING 8-HYDROXYDEOXYGUANINE.ADENINE BASE-PAIRS~~'''~~

===CRYSTAL STRUCTURE OF A DNA DUPLEX CONTAINING 8-HYDROXYDEOXYGUANINE.ADENINE BASE-PAIRS===

~~==Overview==~~

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The ~~crystal structure of~~ the ~~oligonucleotide d(CGCAAATTO8GGCG), containing~~ the ~~chemically modified base 8-hydroxydeoxyguanine~~ (~~O8G), has been determined~~ at 2.~~5-A resolution and refined to a crystallographic R-factor of 16~~.~~8%. The B-type DNA helix contains standard Watson-Crick base pairs except at the mismatch sites~~, where ~~O8G adopts a syn conformation and forms hydrogen bonds to adenine in~~ the ~~anti conformation~~. The thermodynamic stability of the duplex was found by UV melting techniques to be intermediate between the native oligonucleotide d(CGCAAATTTGCG) and an oligonucleotide containing A.G mispairs d(CGCAAATTGGCG). Comparison of the structure of the O8G(syn).A(anti) base pair with those of Watson-~~Crick base pairs has given a reason why O8G.A base pairs are not well repaired by DNA proofreading enzymes.~~

The line below this paragraph, {{ABSTRACT_PUBMED_8068665}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 8068665 is the PubMed ID number.

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==About this Structure==

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[[Category: Mismatched]]

[[Category: Modified]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 09~~:33:32 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 15:36:31 2008''

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-[[Image:178d.gif|left|200px]]
+{{Seed}}
+[[Image:178d.png|left|200px]]
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 {{STRUCTURE_178d|  PDB=178d  |  SCENE=  }}
-'''CRYSTAL STRUCTURE OF A DNA DUPLEX CONTAINING 8-HYDROXYDEOXYGUANINE.ADENINE BASE-PAIRS'''
+===CRYSTAL STRUCTURE OF A DNA DUPLEX CONTAINING 8-HYDROXYDEOXYGUANINE.ADENINE BASE-PAIRS===
-==Overview==
+<!--
-The crystal structure of the oligonucleotide d(CGCAAATTO8GGCG), containing the chemically modified base 8-hydroxydeoxyguanine (O8G), has been determined at 2.5-A resolution and refined to a crystallographic R-factor of 16.8%. The B-type DNA helix contains standard Watson-Crick base pairs except at the mismatch sites, where O8G adopts a syn conformation and forms hydrogen bonds to adenine in the anti conformation. The thermodynamic stability of the duplex was found by UV melting techniques to be intermediate between the native oligonucleotide d(CGCAAATTTGCG) and an oligonucleotide containing A.G mispairs d(CGCAAATTGGCG). Comparison of the structure of the O8G(syn).A(anti) base pair with those of Watson-Crick base pairs has given a reason why O8G.A base pairs are not well repaired by DNA proofreading enzymes.
+The line below this paragraph, {{ABSTRACT_PUBMED_8068665}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 8068665 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_8068665}}
 ==About this Structure==
@@ Line 31: / Line 35: @@
 [[Category: Mismatched]]
 [[Category: Modified]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 09:33:32 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 15:36:31 2008''