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| {{STRUCTURE_192d| PDB=192d | SCENE= }} | | {{STRUCTURE_192d| PDB=192d | SCENE= }} |
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| '''RECOMBINATION-LIKE STRUCTURE OF D(CCGCGG)'''
| | ===RECOMBINATION-LIKE STRUCTURE OF D(CCGCGG)=== |
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| ==Overview==
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| We have solved the single crystal X-ray structure of the synthetic DNA hexamer d(CCGCGG). The central alternating tetramer forms a Z-DNA duplex. The initial cytosine of each strand of the duplex swings out and forms a Watson-Crick base-pair with the terminal guanine of a symmetry-related molecule. Thus, two symmetry-related DNA molecules form a twin with intermolecular base-pairs at both ends. Such a twin is additionally stabilized by a sodium ion located on a dyad axis between two DNA duplexes. The total structure has recombination-like features. It also provides a model for B/Z junctions. The crystal used in this study belongs to space group C222(1) with a = 34.33 A, b = 44.04 A and c = 38.27 A. The structure was solved by molecular replacement using partial models, and refined by molecular dynamics simulated annealing and positional treatment. The refinement has been concluded with an R-factor of 18.5% for 2377 reflections with F > or = 2 sigma (F) in the resolution region 8.0 to 1.92 A. The asymmetric unit contains two strands of d(CCGCGG) and 38 water molecules.
| | The line below this paragraph, {{ABSTRACT_PUBMED_7966274}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 7966274 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_7966274}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Flipped-out base]] | | [[Category: Flipped-out base]] |
| [[Category: Z-dna]] | | [[Category: Z-dna]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:35:06 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 15:39:41 2008'' |
