1a3o: Difference between revisions

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[[Image:1a3o.gif|left|200px]]
{{Seed}}
[[Image:1a3o.png|left|200px]]


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{{STRUCTURE_1a3o|  PDB=1a3o  |  SCENE=  }}  
{{STRUCTURE_1a3o|  PDB=1a3o  |  SCENE=  }}  


'''ARTIFICIAL MUTANT (ALPHA Y42H) OF DEOXY HEMOGLOBIN'''
===ARTIFICIAL MUTANT (ALPHA Y42H) OF DEOXY HEMOGLOBIN===




==Overview==
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The structures of deoxy human haemoglobin and an artificial mutant (Tyralpha42--&gt;His) have been solved at 120 K. While overall agreement between these structures and others in the PDB is very good, certain side chains are found to be shifted, absent from the electron-density map or in different rotamers. Non-crystallographic symmetry (NCS) is very well obeyed in the native protein, but not around the site of the changed residue in the mutant. NCS is also not obeyed by the water molecule invariably found in the alpha-chain haem pocket in room-temperature crystal structures of haemoglobin. At 120 K, this water molecule disappears from one alpha chain in the asymmetric unit but not the other.
The line below this paragraph, {{ABSTRACT_PUBMED_10930827}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 10930827 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10930827}}


==About this Structure==
==About this Structure==
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[[Category: Oxygen transport]]
[[Category: Oxygen transport]]
[[Category: Respiratory protein]]
[[Category: Respiratory protein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 09:45:55 2008''
 
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