1a41: Difference between revisions

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[[Image:1a41.~~gif~~|left|200px]]

[[Image:1a41.png|left|200px]]

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~~'''~~TYPE 1-TOPOISOMERASE CATALYTIC FRAGMENT FROM VACCINIA VIRUS~~'''~~

===TYPE 1-TOPOISOMERASE CATALYTIC FRAGMENT FROM VACCINIA VIRUS===

~~==Overview==~~

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~~Vaccinia DNA topoisomerase breaks and rejoins DNA strands through a DNA~~-~~(3'~~-~~phosphotyrosyl)-enzyme intermediate. A C-terminal catalytic domain, Topo(81-314), suffices for transesterification chemistry.~~ The ~~domain contains a constellation of five amino acids~~, ~~conserved in all eukaryotic type IB topoisomerases~~, ~~that catalyzes attack of~~ the ~~tyrosine nucleophile~~ on ~~the scissile phosphate~~. ~~The structure of the catalytic domain~~, ~~consisting of ten alpha helices and a three-strand beta sheet, resembles~~ the ~~catalytic domains of site~~-~~specific recombinases that act via a topoisomerase IB~~-like mechanism. The topoisomerase catalytic pentad is conserved in the tertiary structures of the recombinases despite scant sequence similarity overall. This implies that the catalytic domains of type IB topoisomerases and recombinases derive from a common ancestral strand transferase.

The line below this paragraph, {{ABSTRACT_PUBMED_9529259}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 9529259 is the PubMed ID number.

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==About this Structure==

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[[Category: Isomerase]]

[[Category: Type 1b topoisomerase]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 09~~:46:46 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 15:59:15 2008''

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-[[Image:1a41.gif|left|200px]]
+{{Seed}}
+[[Image:1a41.png|left|200px]]
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 {{STRUCTURE_1a41|  PDB=1a41  |  SCENE=  }}
-'''TYPE 1-TOPOISOMERASE CATALYTIC FRAGMENT FROM VACCINIA VIRUS'''
+===TYPE 1-TOPOISOMERASE CATALYTIC FRAGMENT FROM VACCINIA VIRUS===
-==Overview==
+<!--
-Vaccinia DNA topoisomerase breaks and rejoins DNA strands through a DNA-(3'-phosphotyrosyl)-enzyme intermediate. A C-terminal catalytic domain, Topo(81-314), suffices for transesterification chemistry. The domain contains a constellation of five amino acids, conserved in all eukaryotic type IB topoisomerases, that catalyzes attack of the tyrosine nucleophile on the scissile phosphate. The structure of the catalytic domain, consisting of ten alpha helices and a three-strand beta sheet, resembles the catalytic domains of site-specific recombinases that act via a topoisomerase IB-like mechanism. The topoisomerase catalytic pentad is conserved in the tertiary structures of the recombinases despite scant sequence similarity overall. This implies that the catalytic domains of type IB topoisomerases and recombinases derive from a common ancestral strand transferase.
+The line below this paragraph, {{ABSTRACT_PUBMED_9529259}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 9529259 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_9529259}}
 ==About this Structure==
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 [[Category: Isomerase]]
 [[Category: Type 1b topoisomerase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 09:46:46 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 15:59:15 2008''