1a4f: Difference between revisions

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[[Image:1a4f.gif|left|200px]]
{{Seed}}
[[Image:1a4f.png|left|200px]]


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{{STRUCTURE_1a4f|  PDB=1a4f  |  SCENE=  }}  
{{STRUCTURE_1a4f|  PDB=1a4f  |  SCENE=  }}  


'''BAR-HEADED GOOSE HEMOGLOBIN (OXY FORM)'''
===BAR-HEADED GOOSE HEMOGLOBIN (OXY FORM)===




==Overview==
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We have determined the crystal structure of bar-headed goose haemoglobin in the oxy form to a resolution of 2.0 A. The R-factor of the model is 19.8%. The structure is similar to human HbA, but contacts between the subunits show slightly altered packing of the tetramer. Bar-headed goose blood shows a greatly elevated oxygen affinity compared to closely related species of geese. This is apparently due to a single proline to alanine mutation at the alpha 1 beta 1 interface which destabilises the T state of the protein. The beta chain N and C termini are well-localized, and together with other neighbouring basic groups they form a strongly positively charged groove at the entrance to the central cavity around the molecular dyad. The well-ordered conformation and the three-dimensional distribution of positive charges clearly indicate this area to be the inositol pentaphosphate binding site of bird haemoglobins.
The line below this paragraph, {{ABSTRACT_PUBMED_8568892}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 8568892 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8568892}}


==About this Structure==
==About this Structure==
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[[Category: Oxygen transport]]
[[Category: Oxygen transport]]
[[Category: Respiratory protein]]
[[Category: Respiratory protein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 09:47:51 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:05:59 2008''

Revision as of 13:06, 30 June 2008

File:1a4f.png

Template:STRUCTURE 1a4f

BAR-HEADED GOOSE HEMOGLOBIN (OXY FORM)

Template:ABSTRACT PUBMED 8568892

About this Structure

1A4F is a Protein complex structure of sequences from Anser indicus. Full crystallographic information is available from OCA.

Reference

The crystal structure of a high oxygen affinity species of haemoglobin (bar-headed goose haemoglobin in the oxy form)., Zhang J, Hua Z, Tame JR, Lu G, Zhang R, Gu X, J Mol Biol. 1996 Jan 26;255(3):484-93. PMID:8568892

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