1a58: Difference between revisions

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[[Image:1a58.gif|left|200px]]
{{Seed}}
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{{STRUCTURE_1a58|  PDB=1a58  |  SCENE=  }}  
{{STRUCTURE_1a58|  PDB=1a58  |  SCENE=  }}  


'''CYCLOPHILIN FROM BRUGIA MALAYI'''
===CYCLOPHILIN FROM BRUGIA MALAYI===




==Overview==
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A structure of residues 1-177 of the cyclophilin domain of a large divergent cyclophilin from the filarial nematode parasite Brugia malayi has been crystallised and solved in two different crystal forms. The active site has a similar structure to that of human cyclophilin A. Two of the 13 residues important in forming the human cyclophilin A/cyclosporin A complex are altered in the B. malayi cyclophilin and explain the relatively poor inhibition of peptidyl prolyl isomerase activity by cyclosporin A.
The line below this paragraph, {{ABSTRACT_PUBMED_9559680}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_9559680}}


==About this Structure==
==About this Structure==
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[[Category: Isomerase]]
[[Category: Isomerase]]
[[Category: Ppiase]]
[[Category: Ppiase]]
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